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MAPK1 [cytosol]
Stable Identifier
R-CFA-59282
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
MAPK1, A0A8I3PZP0
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
L1CAM interactions (Canis familiaris)
Signal transduction by L1 (Canis familiaris)
MAP2K2 phosphorylates MAPK1 (Canis familiaris)
p-S,T-MAP2K2:MAPK1 [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Thrombin signalling through proteinase activated receptors (PARs) (Canis familiaris)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Canis familiaris)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
F2R:ARRB1 binds MAPKs, SRC-1 (Canis familiaris)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
F2R:ARRB2 binds MAPKs, SRC-1 (Canis familiaris)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
SRC-1 bound to ARRB2 is not activated (Canis familiaris)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Canis familiaris)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Growth hormone receptor signaling (Canis familiaris)
Lyn activates ERK (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
Interferon Signaling (Canis familiaris)
Interferon gamma signaling (Canis familiaris)
IFNG signaling activates MAPKs (Canis familiaris)
JAK1-activated RAF1 phosphorylates MAPKs (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF-independent MAPK1/3 activation (Canis familiaris)
Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)
MAPK monomers and dimers [cytosol] (Canis familiaris)
MAPK1 dimer [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
MAPK1 (ERK2) activation (Canis familiaris)
MAP2K2 binds MAPK1 (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
p-S,T-MAP2K2:MAPK1 [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
MAP2K2 phosphorylates MAPK1 (Canis familiaris)
p-S,T-MAP2K2:MAPK1 [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
MAP2K and MAPK activation (Canis familiaris)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
IL17RD binds p-2S MAP2Ks and MAPKs (Canis familiaris)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Canis familiaris)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Canis familiaris)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
MAP2Ks phosphorylate MAPKs (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
RAF phosphorylates MAP2K dimer (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
Negative regulation of MAPK pathway (Canis familiaris)
Cytosolic DUSPs dephosphorylate MAPKs (Canis familiaris)
MAPK monomers and dimers [cytosol] (Canis familiaris)
MAPK1 dimer [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
MAPKs [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by Insulin receptor (Canis familiaris)
Insulin receptor signalling cascade (Canis familiaris)
Signal attenuation (Canis familiaris)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Canis familiaris)
MAPK3,(MAPK1) [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Canis familiaris)
MAPK3,(MAPK1) [cytosol] (Canis familiaris)
MAPK1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3PZP0
Gene Names
MAPK1
Reference Genes
BioGPS Gene:477575 MAPK1
ENSEMBL:ENSCAFG00845026389.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845026389.1 MAPK1
KEGG Gene (Canis lupus familiaris):477575 MAPK1
Monarch:477575 MAPK1
NCBI Gene:477575 MAPK1
Reference Transcript
RefSeq:NM_001110800.1 MAPK1
Other Identifiers
477575
Cfa.2796.1.A1_at
Cfa.9893.1.S1_at
CfaAffx.23699.1.S1_at
CfaAffx.23699.1.S1_s_at
GO:0000165
GO:0001784
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0006468
GO:0006974
GO:0007507
GO:0008286
GO:0008353
GO:0009887
GO:0010759
GO:0010800
GO:0014032
GO:0014044
GO:0016301
GO:0016740
GO:0019858
GO:0019902
GO:0023052
GO:0030154
GO:0030278
GO:0030521
GO:0030641
GO:0030878
GO:0031143
GO:0031663
GO:0032200
GO:0032212
GO:0032496
GO:0033598
GO:0034198
GO:0034614
GO:0035094
GO:0036211
GO:0038127
GO:0038133
GO:0042473
GO:0042552
GO:0042802
GO:0043226
GO:0043330
GO:0043401
GO:0045596
GO:0048009
GO:0048538
GO:0048856
GO:0048870
GO:0050847
GO:0050852
GO:0050853
GO:0051403
GO:0055086
GO:0060020
GO:0060291
GO:0060324
GO:0060425
GO:0060440
GO:0060716
GO:0061308
GO:0070371
GO:0070849
GO:0071276
GO:0071356
GO:0120041
GO:0140096
GO:1904355
Participates
as a component of
MAPK1 dimer [cytosol] (Canis familiaris)
p-S,T-MAP2K2:MAPK1 [cytosol] (Canis familiaris)
as an input of
MAP2K2 binds MAPK1 (Canis familiaris)
as a candidate of
MAPK3,(MAPK1) [cytosol] (Canis familiaris)
as a member of
MAPKs [cytosol] (Canis familiaris)
Other forms of this molecule
MAPK1 [ficolin-1-rich granule lumen]
MAPK1 [extracellular region]
MAPK1 [azurophil granule lumen]
MAPK1 [nucleoplasm]
phospho-MAPK1 [cytosol]
phospho-MAPK1 [nucleoplasm]
Inferred From
MAPK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001104270.1
OpenTargets
ENSG00000100030
Ensembl
ENSCAFP00845036530
,
ENSCAFG00845026389
,
ENSCAFT00845046534
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