Reactome | CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane]

CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-CFA-5689804

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Synonyms

GPI-CD59, A0A8I3PTW0

Locations in the PathwayBrowser

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Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Asparagine N-linked glycosylation (Canis familiaris)
    - Transport to the Golgi and subsequent modification (Canis familiaris)
      - ER to Golgi Anterograde Transport (Canis familiaris)
        
        COPI-mediated anterograde transport (Canis familiaris)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Canis familiaris)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        ARFGAPs stimulate ARF GTPase activity (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        COPII-mediated vesicle transport (Canis familiaris)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - ER to Golgi Anterograde Transport (Canis familiaris)
    - COPI-mediated anterograde transport (Canis familiaris)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Canis familiaris)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
      - ARFGAPs stimulate ARF GTPase activity (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        ERGIC-to-cis-Golgi cargo [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
    - COPII-mediated vesicle transport (Canis familiaris)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Canis familiaris)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PTW0

Gene Names

CD59

Reference Genes

BioGPS Gene:475945 CD59

ENSEMBL:ENSCAFG00845025193.1

KEGG:cfa:475945 CD59

Monarch:475945 CD59

NCBI Gene:475945 CD59

UCSC:A0A8I3PTW0 CD59

Reference Transcript

Other Identifiers

475945

Cfa.838.1.A1_at

CfaAffx.11657.1.S1_s_at

GO:0001848

GO:0001971

GO:0005886

GO:0016020

GO:0098552

Participates

as a member of

GPI-CD59, GPI-FOLR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

Other forms of this molecule

CD59 [ER to Golgi transport vesicle membrane]

CD59 [endoplasmic reticulum membrane]

CD59 [Golgi membrane]

CD59 [transport vesicle]

CD59 [tertiary granule membrane]

CD59 [specific granule membrane]

CD59 [plasma membrane]

Inferred From

GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Modified Residues

Name

L-asparagine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 102 (in Homo sapiens)

Coordinate

102

Modification

GPI-anchor amidated amino acid carboxyl end residue(1−)

PsiMod Name

L-asparagine amide

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to L-asparagine amide.

Cross References

RefSeq

XP_533156.1, XP_022261044.1, XP_038280067.1, XP_038280068.1

ENSEMBL

ENSCAFG00845025193, ENSCAFT00845044454, ENSCAFP00845034832

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