Reactome | BABAM2 [nucleoplasm]

BABAM2 [nucleoplasm]

Stable Identifier

R-CFA-5682579

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

BRE, A0A8I3NEH3

Locations in the PathwayBrowser

Expand all

Cell Cycle (Canis familiaris)

- Cell Cycle Checkpoints (Canis familiaris)
  - G2/M Checkpoints (Canis familiaris)
    - G2/M DNA damage checkpoint (Canis familiaris)
      - CHEK2 is recruited to DNA DSBs (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
      - Phosphorylation and activation of CHEK2 by ATM (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)

DNA Repair (Canis familiaris)

- DNA Double-Strand Break Repair (Canis familiaris)
  - DNA Double Strand Break Response (Canis familiaris)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
      - CHEK2 is recruited to DNA DSBs (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
      - CHEK2 phosphorylates BRCA1 (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
      - Formation of BRCA1-A complex at DNA DSBs (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
      - Phosphorylation and activation of CHEK2 by ATM (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
      - Phosphorylation of BRCA1-A complex at multiple sites by ATM (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)
  - Nonhomologous End-Joining (NHEJ) (Canis familiaris)
    - RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Canis familiaris)
      - BABAM2 [nucleoplasm] (Canis familiaris)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        BABAM2 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NEH3

Gene Names

BABAM2

Reference Genes

BioGPS Gene:475711 BABAM2

ENSEMBL:ENSCAFG00845010142.1

Monarch:475711 BABAM2

NCBI Gene:475711 BABAM2

UCSC:A0A8I3NEH3 BABAM2

Reference Transcript

Other Identifiers

475711

Cfa.14120.1.A1_at

Cfa.14120.1.A1_s_at

CfaAffx.8760.1.S1_s_at

GO:0000152

GO:0005164

GO:0005634

GO:0005737

GO:0005829

GO:0006281

GO:0006302

GO:0006325

GO:0006915

GO:0006974

GO:0007095

GO:0010212

GO:0031593

GO:0043066

GO:0045739

GO:0051301

GO:0070531

GO:0070552

GO:0071479

Participates

as an output of

RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Canis familiaris)

as a component of

as an input of

Formation of BRCA1-A complex at DNA DSBs (Canis familiaris)

Other forms of this molecule

BABAM2 [cytosol]

Inferred From

BRE [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_038547030.1, XP_038417060.1, XP_038547032.1, XP_038417061.1, XP_038309109.1, XP_038547031.1, XP_038309111.1, XP_038309110.1, XP_038417059.1

ENSEMBL

ENSCAFG00845010142, ENSCAFT00845017972, ENSCAFP00845014001

Cite Us!