Reactome | MTA2 [nucleoplasm]

MTA2 [nucleoplasm]

Stable Identifier

R-CFA-4657009

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

MTA2, A0A8I3N2N1

Locations in the PathwayBrowser

Expand all

Chromatin organization (Canis familiaris)

- Chromatin modifying enzymes (Canis familiaris)
  - HDACs deacetylate histones (Canis familiaris)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Canis familiaris)
      - HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Canis familiaris)
        
        MTA2 [nucleoplasm] (Canis familiaris)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Canis familiaris)
        
        HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Canis familiaris)
        
        MTA2 [nucleoplasm] (Canis familiaris)
    - HDAC1:2-containing complex deacetylate histones (Canis familiaris)
      - HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Canis familiaris)
        
        MTA2 [nucleoplasm] (Canis familiaris)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Canis familiaris)
        
        HDAC1:2-containing complex [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Canis familiaris)
        
        MTA2 [nucleoplasm] (Canis familiaris)

Gene expression (Transcription) (Canis familiaris)

- RNA Polymerase I Transcription (Canis familiaris)
  - RNA Polymerase I Promoter Clearance (Canis familiaris)
    - RNA Polymerase I Transcription Initiation (Canis familiaris)
      - Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Canis familiaris)
        
        TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Canis familiaris)
        
        MTA2 [nucleoplasm] (Canis familiaris)
- RNA Polymerase II Transcription (Canis familiaris)
  - Generic Transcription Pathway (Canis familiaris)
    - Transcriptional Regulation by TP53 (Canis familiaris)
      - Regulation of TP53 Activity (Canis familiaris)
        
        Regulation of TP53 Activity through Acetylation (Canis familiaris)
        
        MTA2-NuRD complex deacetylates TP53 (Canis familiaris)
        
        MTA2-NuRD complex [nucleoplasm] (Canis familiaris)
        
        MTA2 [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - PTEN Regulation (Canis familiaris)
      - Regulation of PTEN gene transcription (Canis familiaris)
        
        SALL4 recruits NuRD to PTEN gene (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Canis familiaris)
        
        MTA2 [nucleoplasm] (Canis familiaris)
        
        SALL4:NuRD:PTEN gene [nucleoplasm] (Canis familiaris)
        
        SALL4:NuRD [nucleoplasm] (Canis familiaris)
        
        NuRD complex [nucleoplasm] (Canis familiaris)
        
        MTA1, MTA2, MTA3 [nucleoplasm] (Canis familiaris)
        
        MTA2 [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N2N1

Gene Names

MTA2

Reference Genes

BioGPS Gene:476057 MTA2

ENSEMBL:ENSCAFG00845009498.1

Monarch:476057 MTA2

NCBI Gene:476057 MTA2

UCSC:A0A8I3N2N1 MTA2

Reference Transcript

RefSeq:XM_533265.5 MTA2

Other Identifiers

476057

CfaAffx.24228.1.S1_at

GO:0000118

GO:0000122

GO:0000781

GO:0003677

GO:0003682

GO:0003712

GO:0003713

GO:0003714

GO:0003824

GO:0004407

GO:0005634

GO:0005654

GO:0005667

GO:0006325

GO:0006338

GO:0006355

GO:0016581

GO:0016787

GO:0042826

GO:0043226

GO:0043565

GO:0045892

GO:0045944

GO:0046872

GO:0060090

GO:0061629

GO:0071514

GO:0140096

GO:0140110

Participates

as a component of

MTA2-NuRD complex [nucleoplasm] (Canis familiaris)

as a member of

MTA1, MTA2, MTA3 [nucleoplasm] (Canis familiaris)

Inferred From

MTA2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_533265.2

ENSEMBL

ENSCAFG00845009498, ENSCAFT00845016756, ENSCAFP00845013032