Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
JAK3 [cytosol]
Stable Identifier
R-CFA-451893
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
A0A8I3S4Z2
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-2 family signaling (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Phosphorylated SHC1 recruits SHIP (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin-15 signaling (Canis familiaris)
IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Canis familiaris)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Canis familiaris)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin-2 signaling (Canis familiaris)
JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK3 binds JAK3 inhibitors (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK3:JAK3 inhibitors [cytosol] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
PTK2B binds JAK3 (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK3:PYK2 [cytosol] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
PTK2B is phosphorylated (Canis familiaris)
JAK3:PYK2 [cytosol] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK3:p-PYK2 [cytosol] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Phosphorylated STAT5 is released (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Recruited STAT5 is phosphorylated (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
SHC1 bound to IL2 receptor is phosphorylated (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
SYK binds IL2RB (Canis familiaris)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Canis familiaris)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
SYK is a substrate for JAK1 (Canis familiaris)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Canis familiaris)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Canis familiaris)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Within the IL-2R complex JAK3 phosphorylates JAK1 (Canis familiaris)
IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin-21 signaling (Canis familiaris)
IL21 receptor JAK phosphorylation (Canis familiaris)
IL21:IL21R:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin-9 signaling (Canis familiaris)
IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Canis familiaris)
IL9:IL9R:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK3 binds JAK3 inhibitors (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK3:JAK3 inhibitors [cytosol] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin-20 family signaling (Canis familiaris)
IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Canis familiaris)
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane] (Canis familiaris)
JAK2, JAK3 [cytosol] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK2, JAK3 [cytosol] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Canis familiaris)
IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane] (Canis familiaris)
JAK2, JAK3 [cytosol] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Phosphorylated SHC1 recruits SHIP (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin-4 and Interleukin-13 signaling (Canis familiaris)
IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Canis familiaris)
IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Canis familiaris)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK1 binds IL4R in IL4-bound IL4R1 (Canis familiaris)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Canis familiaris)
IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK3 binds JAK3 inhibitors (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK3:JAK3 inhibitors [cytosol] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
STAT3,STAT6 bind p-Y-IL4R (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
p-Y705-STAT3,p-Y641-STAT6 dissociate (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Interleukin-7 signaling (Canis familiaris)
JAK3 binds JAK3 inhibitors (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK3:JAK3 inhibitors [cytosol] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Canis familiaris)
IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
Active ALK binds JAK3 (Canis familiaris)
Active ALK:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
Active ALK phosphorylates JAK3 (Canis familiaris)
Active ALK:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
PTPN6 dephosphorylates JAK3 (Canis familiaris)
Active ALK:JAK3 [plasma membrane] (Canis familiaris)
JAK3 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3S4Z2
Reference Genes
ENSEMBL:ENSCAFG00845024918.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845024918.1
Other Identifiers
403436
610004
Cfa.139.1.A1_at
Cfa.139.2.S1_s_at
CfaAffx.23353.1.S1_at
GO:0000166
GO:0002250
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005524
GO:0005856
GO:0005886
GO:0006468
GO:0012505
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019221
GO:0019903
GO:0023052
GO:0031234
GO:0035556
GO:0035723
GO:0035771
GO:0036211
GO:0038110
GO:0038113
GO:0043226
GO:0070670
GO:0140096
Participates
as a candidate of
JAK2, JAK3 [cytosol] (Canis familiaris)
as an input of
Active ALK binds JAK3 (Canis familiaris)
PTK2B binds JAK3 (Canis familiaris)
JAK3 binds JAK3 inhibitors (Canis familiaris)
as a component of
Active ALK:JAK3 [plasma membrane] (Canis familiaris)
JAK3:p-PYK2 [cytosol] (Canis familiaris)
JAK3:PYK2 [cytosol] (Canis familiaris)
p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
JAK3:JAK3 inhibitors [cytosol] (Canis familiaris)
IL2RG:JAK3 [plasma membrane] (Canis familiaris)
Other forms of this molecule
phospho-p-Y980 JAK3 [cytosol]
JAK3 [endosome]
phospho-p-JAK3 [cytosol]
phospho-p-Y-JAK3 [cytosol]
phospho-p-Y904,939-JAK3 [plasma membrane]
Inferred From
JAK3 [cytosol]
(Homo sapiens)
Cross References
Ensembl
ENSCAFG00845024918
,
ENSCAFT00845044226
,
ENSCAFT00845043981
,
ENSCAFP00845034466
,
ENSCAFP00845034660
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text