Reactome | JAK3 [cytosol]

JAK3 [cytosol]

Stable Identifier

R-CFA-451893

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

E2RG40

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-2 family signaling (Canis familiaris)
      - Interleukin receptor SHC signaling (Canis familiaris)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - Interleukin-15 signaling (Canis familiaris)
        
        IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Canis familiaris)
        
        IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Canis familiaris)
        
        IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Canis familiaris)
        
        IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Canis familiaris)
        
        IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - Interleukin-2 signaling (Canis familiaris)
        
        IL2RG binds JAK3 (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        PTK2B binds JAK3 (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3:PYK2 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        PTK2B is phosphorylated (Canis familiaris)
        
        JAK3:PYK2 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3:p-PYK2 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - Interleukin-21 signaling (Canis familiaris)
        
        IL21 receptor JAK phosphorylation (Canis familiaris)
        
        IL21:IL21R:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL21:IL21R:JAK1 binds IL2RG:JAK3 (Canis familiaris)
        
        IL21:IL21R:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - Interleukin-9 signaling (Canis familiaris)
        
        IL2RG binds JAK3 (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Canis familiaris)
        
        IL9:IL9R:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
    - Interleukin-20 family signaling (Canis familiaris)
      - IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Canis familiaris)
        
        IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane] (Canis familiaris)
        
        JAK2, JAK3 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK2, JAK3 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Canis familiaris)
        
        IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane] (Canis familiaris)
        
        JAK2, JAK3 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
      - Interleukin receptor SHC signaling (Canis familiaris)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
    - Interleukin-4 and Interleukin-13 signaling (Canis familiaris)
      - IL2RG binds JAK3 (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - IL4:IL4R:JAK2 binds IL2RG:JAK3 (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Canis familiaris)
        
        IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - JAK1 binds IL4R in IL4-bound IL4R1 (Canis familiaris)
        
        IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - STAT3,STAT6 bind p-Y-IL4R (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - p-Y705-STAT3,p-Y641-STAT6 dissociate (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
    - Interleukin-7 signaling (Canis familiaris)
      - IL2RG binds JAK3 (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Canis familiaris)
        
        IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2RG40

Reference Genes

ENSEMBL:ENSCAFG00000015159

Other Identifiers

610004

AAEX03012289

CfaAffx.23353.1.S1_at

ENSCAFG00000015159

ENSCAFP00000022374

ENSCAFT00000024100

EntrezGene:610004

GO:0000166

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005856

GO:0006464

GO:0006468

GO:0007155

GO:0007165

GO:0007260

GO:0008150

GO:0008283

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0019221

GO:0019899

GO:0019903

GO:0030154

GO:0030183

GO:0030218

GO:0035556

GO:0035771

GO:0042102

GO:0042592

GO:0043029

GO:0043167

GO:0043226

GO:0048856

GO:0070670

IPR000299

IPR000719

IPR000980

IPR001245

IPR008266

IPR011009

IPR016251

IPR017441

IPR019749

IPR020635

IPR020775

J9P769

JAK3

JAK3-202

PF07714

PR00109

PR01823

PR01826

SM00219

SM00252

SM00295

UPI000274784A

VGNC:42177

XM_005632717

XP_005632774

Participant Of

hasCandidate

JAK2, JAK3 [cytosol]

input

hasComponent

Other forms of this molecule

phospho-p-Y904,939-JAK3 [plasma membrane]

JAK3 [endosome]

phospho-p-Y-JAK3 [cytosol]

phospho-p-JAK3 [cytosol]

Inferred From

JAK3 [cytosol] (Homo sapiens)