Reactome | JAK3 [cytosol]

JAK3 [cytosol]

Stable Identifier

R-CFA-451893

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

A0A8I3S4Z2

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-2 family signaling (Canis familiaris)
      - Interleukin receptor SHC signaling (Canis familiaris)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC1 recruits SHIP (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - Interleukin-15 signaling (Canis familiaris)
        
        IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Canis familiaris)
        
        IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Canis familiaris)
        
        IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - Interleukin-2 signaling (Canis familiaris)
        
        JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3 binds JAK3 inhibitors (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3:JAK3 inhibitors [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        PTK2B binds JAK3 (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3:PYK2 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        PTK2B is phosphorylated (Canis familiaris)
        
        JAK3:PYK2 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3:p-PYK2 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Phosphorylated STAT5 is released (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Phosphorylation of IL2RB Y338 enables SHC recruitment (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Recruited STAT5 is phosphorylated (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        SHC1 bound to IL2 receptor is phosphorylated (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        SYK binds IL2RB (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        SYK is a substrate for JAK1 (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Within the IL-2R complex JAK3 phosphorylates JAK1 (Canis familiaris)
        
        IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - Interleukin-21 signaling (Canis familiaris)
        
        IL21 receptor JAK phosphorylation (Canis familiaris)
        
        IL21:IL21R:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - Interleukin-9 signaling (Canis familiaris)
        
        IL9:IL9R:JAK1:IL2RG:JAK3 phosphorylates JAK3 (Canis familiaris)
        
        IL9:IL9R:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3 binds JAK3 inhibitors (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3:JAK3 inhibitors [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
    - Interleukin-20 family signaling (Canis familiaris)
      - IL20:IL20RA:JAK1:IL20RB binds JAK2,JAK3 (Canis familiaris)
        
        IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane] (Canis familiaris)
        
        JAK2, JAK3 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK2, JAK3 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3 (Canis familiaris)
        
        IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 [plasma membrane] (Canis familiaris)
        
        JAK2, JAK3 [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
      - Interleukin receptor SHC signaling (Canis familiaris)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Phosphorylated SHC1 recruits SHIP (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Canis familiaris)
        
        IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
    - Interleukin-4 and Interleukin-13 signaling (Canis familiaris)
      - IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated (Canis familiaris)
        
        IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - JAK1 binds IL4R in IL4-bound IL4R1 (Canis familiaris)
        
        IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - JAK1 phosphorylates STAT3,STAT6 (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - JAK3 binds JAK3 inhibitors (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3:JAK3 inhibitors [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - STAT3,STAT6 bind p-Y-IL4R (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:STAT3,STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - p-Y705-STAT3,p-Y641-STAT6 dissociate (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1:p-Y705-STAT3,p-Y641-STAT6 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3:p-Y-JAK1 [plasma membrane] (Canis familiaris)
        
        IL4:p-Y-IL4R:JAK2:p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        p-Y-IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
    - Interleukin-7 signaling (Canis familiaris)
      - JAK3 binds JAK3 inhibitors (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
        
        JAK3:JAK3 inhibitors [cytosol] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)
      - JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated (Canis familiaris)
        
        IL7:IL7R:JAK1:IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        IL2RG:JAK3 [plasma membrane] (Canis familiaris)
        
        JAK3 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S4Z2

Reference Genes

BioGPS Gene:610004

ENSEMBL:ENSCAFG00845024918.1

Monarch:610004

NCBI Gene:610004

UCSC:A0A8I3S4Z2

Reference Transcript

RefSeq:XM_038428207.1

Other Identifiers

403436

610004

Cfa.139.1.A1_at

Cfa.139.2.S1_s_at

CfaAffx.23353.1.S1_at

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005524

GO:0005856

GO:0006468

GO:0016020

GO:0016740

GO:0019221

GO:0019903

GO:0022407

GO:0031234

GO:0035556

GO:0035723

GO:0035771

GO:0038110

GO:0038111

GO:0038113

GO:0043226

GO:0050865

GO:0070670

GO:0140096

GO:2000329

Participates

as a candidate of

JAK2, JAK3 [cytosol] (Canis familiaris)

as an input of

as a component of

Other forms of this molecule

phospho-p-Y980 JAK3 [cytosol]

phospho-p-Y904,939-JAK3 [plasma membrane]

JAK3 [endosome]

phospho-p-JAK3 [cytosol]

phospho-p-Y-JAK3 [cytosol]

Inferred From

JAK3 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038284135.1

ENSEMBL

ENSCAFG00845024918, ENSCAFT00845044226, ENSCAFP00845034660, ENSCAFT00845043981, ENSCAFP00845034466

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