Reactome | MAPK10 [cytosol]

MAPK10 [cytosol]

Stable Identifier

R-CFA-450352

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

MAPK10, A0A8I3PIJ5

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-17 signaling (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK10 [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Fc epsilon receptor (FCERI) signaling (Canis familiaris)
    - FCERI mediated MAPK activation (Canis familiaris)
      - Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK10 [cytosol] (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK10 [cytosol] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK10 [cytosol] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK10 [cytosol] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK10 [cytosol] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK10 [cytosol] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK10 [cytosol] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK10 [cytosol] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK10 [cytosol] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Phosphorylation of human JNKs by activated MKK4/MKK7 (Canis familiaris)
        
        MAPK8,9,10 [cytosol] (Canis familiaris)
        
        MAPK10 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PIJ5

Gene Names

MAPK10

Reference Genes

ENSEMBL:ENSCAFG00845023201.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845023201.1 MAPK10

Other Identifiers

478464

GO:0003824

GO:0004672

GO:0004707

GO:0005524

GO:0005634

GO:0005654

GO:0006468

GO:0016740

GO:0023052

GO:0036211

GO:0043226

GO:0140096

Participates

as a member of

MAPK8,9,10 [cytosol] (Canis familiaris)

Other forms of this molecule

phospho-MAPK10 [cytosol]

phospho-MAPK10 [nucleoplasm]

Inferred From

MAPK10 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000109339

Ensembl

ENSCAFG00845023201, ENSCAFP00845032502, ENSCAFT00845041449

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