Reactome | FOS [nucleoplasm]

FOS [nucleoplasm]

Stable Identifier

R-CFA-450216

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

nucleoplasm

Synonyms

FOS, A0A8I3S1F0

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-17 signaling (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        c-FOS activation by phospho ERK1/2 (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Fc epsilon receptor (FCERI) signaling (Canis familiaris)
    - FCERI mediated MAPK activation (Canis familiaris)
      - c-FOS activation by phospho ERK1/2 (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        c-FOS activation by phospho ERK1/2 (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        c-FOS activation by phospho ERK1/2 (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        c-FOS activation by phospho ERK1/2 (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        c-FOS activation by phospho ERK1/2 (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        c-FOS activation by phospho ERK1/2 (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        c-FOS activation by phospho ERK1/2 (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        c-FOS activation by phospho ERK1/2 (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        c-FOS activation by phospho ERK1/2 (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Canis familiaris)
        
        Activation of the AP-1 family of transcription factors (Canis familiaris)
        
        c-FOS activation by phospho ERK1/2 (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Nuclear Receptors (Canis familiaris)
  - ESR-mediated signaling (Canis familiaris)
    - Estrogen-dependent gene expression (Canis familiaris)
      - Binding of AP1 transcriptional activator complexes to CCND1 promoter (Canis familiaris)
        
        CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Canis familiaris)
        
        ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Canis familiaris)
        
        FOS:JUN [nucleoplasm] (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)
        
        ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Canis familiaris)
        
        FOS:JUN [nucleoplasm] (Canis familiaris)
        
        FOS [nucleoplasm] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S1F0

Gene Names

FOS

Reference Genes

BioGPS Gene:490792 FOS

ENSEMBL:ENSCAFG00845015304.1

KEGG:cfa:490792 FOS

Monarch:490792 FOS

NCBI Gene:490792 FOS

UCSC:A0A8I3S1F0 FOS

Reference Transcript

Other Identifiers

490792

Cfa.9039.1.A1_at

CfaAffx.26065.1.S1_at

GO:0000976

GO:0000978

GO:0000979

GO:0000981

GO:0001221

GO:0001228

GO:0003677

GO:0003682

GO:0003690

GO:0003700

GO:0005634

GO:0005654

GO:0005667

GO:0005737

GO:0005783

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0007179

GO:0007399

GO:0009410

GO:0010468

GO:0030154

GO:0030316

GO:0032993

GO:0034614

GO:0035914

GO:0035976

GO:0035994

GO:0042802

GO:0045672

GO:0045893

GO:0045944

GO:0048856

GO:0060395

GO:0061629

GO:0070412

GO:0071277

GO:0090575

GO:1902895

GO:1990837

Participates

as an input of

c-FOS activation by phospho ERK1/2 (Canis familiaris)

as a component of

FOS:JUN [nucleoplasm] (Canis familiaris)

Other forms of this molecule

phospho-FOS [nucleoplasm]

Inferred From

FOS [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_038399978.1, XP_547914.1, XP_038528903.1

ENSEMBL

ENSCAFG00845015304, ENSCAFT00845027350, ENSCAFP00845021529

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