Reactome | phospho-IRAK2 [cytosol]

phospho-IRAK2 [cytosol]

Stable Identifier

R-CFA-446636

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

p-IRAK2, A0A8I3N5F6

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-1 family signaling (Canis familiaris)
      - Interleukin-1 signaling (Canis familiaris)
        
        IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
    - Interleukin-17 signaling (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
      - TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        MAP kinase activation (Canis familiaris)
        
        JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Canis familiaris)
        
        Activated TAK1 phosphorylates MKK4/MKK7 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        activated TAK1 mediates p38 MAPK activation (Canis familiaris)
        
        activated human TAK1 phosphorylates MKK3/MKK6 (Canis familiaris)
        
        Activated TAK complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Ubiquitination of IKBKG by TRAF6 (Canis familiaris)
        
        K63pUb-TRAF6:TAK1 complexes [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex [cytosol] (Canis familiaris)
        
        p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)
        
        phospho-IRAK2 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3N5F6

Gene Names

IRAK2

Reference Genes

BioGPS Gene:484657 IRAK2

ENSEMBL:ENSCAFG00845008041.1

Monarch:484657 IRAK2

NCBI Gene:484657 IRAK2

UCSC:A0A8I3N5F6 IRAK2

Reference Transcript

RefSeq:XM_014121694.1 IRAK2

Other Identifiers

484657

CfaAffx.8663.1.S1_s_at

GO:0001959

GO:0002376

GO:0003824

GO:0004672

GO:0005524

GO:0007165

GO:0007249

GO:0016740

GO:0031663

GO:0034142

GO:0035591

GO:0042803

GO:0046982

GO:0060090

GO:0070498

GO:0070555

GO:0140096

Participates

as an output of

IRAK2 is phosphorylated downstream of IRAK4 following IL1 receptor activation (Canis familiaris)

as a component of

p-IRAK2:K63-linked pUb oligo-TRAF6 [cytosol] (Canis familiaris)

Other forms of this molecule

phospho-IRAK2 [endosome membrane]

IRAK2 [cytosol]

phospho-IRAK2 [plasma membrane]

Inferred From

p-IRAK2 [cytosol] (Homo sapiens)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

XP_013977169.1

ENSEMBL

ENSCAFT00845014169, ENSCAFP00845010985

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