Reactome | SPTB [cytosol]

SPTB [cytosol]

Stable Identifier

R-CFA-391565

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

SPTB, A0A8I3RS77

Locations in the PathwayBrowser

Expand all

Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - NCAM signaling for neurite out-growth (Canis familiaris)
      - NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Canis familiaris)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
      - Recruitment of Grb2 to pFAK:NCAM1 (Canis familiaris)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
      - SOS binds Grb2 bound to pFAK:NCAM1 (Canis familiaris)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Asparagine N-linked glycosylation (Canis familiaris)
    - Transport to the Golgi and subsequent modification (Canis familiaris)
      - ER to Golgi Anterograde Transport (Canis familiaris)
        
        COPI-mediated anterograde transport (Canis familiaris)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        ARFGAPs stimulate ARF GTPase activity (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        COPI vesicle uncoating (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        ERGIC-to-Golgi vesicles bind dynein:dynactin (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
        
        RAS GEFs [plasma membrane] (Canis familiaris)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - ER to Golgi Anterograde Transport (Canis familiaris)
    - COPI-mediated anterograde transport (Canis familiaris)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
      - ARFGAPs stimulate ARF GTPase activity (Canis familiaris)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
      - COPI vesicle uncoating (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
      - ERGIC-to-Golgi vesicles bind dynein:dynactin (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
      - Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Canis familiaris)
        
        RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
      - cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Canis familiaris)
        
        RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Canis familiaris)
        
        Spectrin tetramer [cytosol] (Canis familiaris)
        
        SPTA:SPTB [cytosol] (Canis familiaris)
        
        Spectrin beta chain [cytosol] (Canis familiaris)
        
        SPTB [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RS77

Gene Names

SPTB

Reference Genes

BioGPS Gene:490734 SPTB

ENSEMBL:ENSCAFG00845002451.1

Monarch:490734 SPTB

NCBI Gene:490734 SPTB

UCSC:A0A8I3RS77 SPTB

Reference Transcript

Other Identifiers

490734

Cfa.19153.1.S1_s_at

CfaAffx.24765.1.S1_s_at

CfaAffx.24793.1.S1_s_at

CfaAffx.24795.1.S1_at

GO:0003779

GO:0005198

GO:0005200

GO:0005515

GO:0005543

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005938

GO:0008091

GO:0008092

GO:0014731

GO:0030036

GO:0030054

GO:0030506

GO:0030863

GO:0030864

GO:0032991

GO:0034330

GO:0042995

GO:0045202

GO:0050808

GO:0051015

GO:0051693

GO:0098885

GO:0098978

Participates

as a member of

Spectrin beta chain [cytosol] (Canis familiaris)

Inferred From

SPTB [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038528848.1, XP_038528847.1, XP_038528846.1

ENSEMBL

ENSCAFG00845002451, ENSCAFP00845003462, ENSCAFT00845004336

Cite Us!