Reactome | DLG1 [plasma membrane]

DLG1 [plasma membrane]

Stable Identifier

R-CFA-375977

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

A0A8I3QNS7

Locations in the PathwayBrowser

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Neuronal System (Canis familiaris)

- Protein-protein interactions at synapses (Canis familiaris)
  - Synaptic adhesion-like molecules (Canis familiaris)
    - SALMs 1-3 bind to PSD-95 family members (Canis familiaris)
      - PSD-95 family [plasma membrane] (Canis familiaris)
        
        DLG1 [plasma membrane] (Canis familiaris)
      - SALMs 1-3:PSD-95 family [plasma membrane] (Canis familiaris)
        
        PSD-95 family [plasma membrane] (Canis familiaris)
        
        DLG1 [plasma membrane] (Canis familiaris)
- Transmission across Chemical Synapses (Canis familiaris)
  - Neurotransmitter receptors and postsynaptic signal transmission (Canis familiaris)
    - Activation of NMDA receptors and postsynaptic events (Canis familiaris)
      - Unblocking of NMDA receptors, glutamate binding and activation (Canis familiaris)
        
        Ca2+ influx into the post-synaptic cell (Canis familiaris)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2 NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Canis familiaris)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Canis familiaris)
        
        DLG1 homotetramer [plasma membrane] (Canis familiaris)
        
        DLG1 [plasma membrane] (Canis familiaris)
    - Activation of kainate receptors upon glutamate binding (Canis familiaris)
      - Ionotropic activity of kainate receptors (Canis familiaris)
        
        Activation of Ca-permeable Kainate Receptor (Canis familiaris)
        
        Activation of Ca-permeable Kainate receptors (Canis familiaris)
        
        Kainate receptor-glutamate complex [plasma membrane] (Canis familiaris)
        
        Kainate Receptors [plasma membrane] (Canis familiaris)
        
        GRIK 2 homomer [plasma membrane] (Canis familiaris)
        
        GRIK2 interacting proteins [plasma membrane] (Canis familiaris)
        
        DLG1 [plasma membrane] (Canis familiaris)
        
        kainate receptor binds glutamate (Canis familiaris)
        
        Kainate Receptors [plasma membrane] (Canis familiaris)
        
        GRIK 2 homomer [plasma membrane] (Canis familiaris)
        
        GRIK2 interacting proteins [plasma membrane] (Canis familiaris)
        
        DLG1 [plasma membrane] (Canis familiaris)
        
        Kainate receptor-glutamate complex [plasma membrane] (Canis familiaris)
        
        Kainate Receptors [plasma membrane] (Canis familiaris)
        
        GRIK 2 homomer [plasma membrane] (Canis familiaris)
        
        GRIK2 interacting proteins [plasma membrane] (Canis familiaris)
        
        DLG1 [plasma membrane] (Canis familiaris)
    - Glutamate binding, activation of AMPA receptors and synaptic plasticity (Canis familiaris)
      - Trafficking of AMPA receptors (Canis familiaris)
        
        Trafficking of GluR1-containing AMPA receptors (Canis familiaris)
        
        DLG1 [plasma membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
        
        RAS GEFs [plasma membrane] (Canis familiaris)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Canis familiaris)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Canis familiaris)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Canis familiaris)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Canis familiaris)
        
        DLG1 homotetramer [plasma membrane] (Canis familiaris)
        
        DLG1 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3QNS7

Reference Genes

BioGPS Gene:488036

ENSEMBL:ENSCAFG00845030548.1

Monarch:488036

NCBI Gene:488036

UCSC:A0A8I3QNS7

Reference Transcript

Participates

as a component of

as a member of

PSD-95 family [plasma membrane] (Canis familiaris)

as an output of

Trafficking of GluR1-containing AMPA receptors (Canis familiaris)

Other forms of this molecule

DLG1 [cytosol]

Inferred From

DLG1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_038301242.1, XP_038439125.1, XP_038318173.1

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