Reactome | GFRA1 [plasma membrane]

GFRA1 [plasma membrane]

Stable Identifier

R-CFA-375067

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

GFRA1, A0A8I3QCB4

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - RET signaling (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind FRS2 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:FRS2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB7,GRB10 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:PLCG1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:RET interactors [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SRC-1,RAP1GAP [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:DOK1,DOK2,DOK4,DOK5,DOK6 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - GDNF,NRTN bind RET:GFRA1,GFRA2 (Canis familiaris)
        
        RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - RET binds GFRA1,GFRA2 (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - RET binds GFRA1,GFRA3 (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA3 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - RET dimerizes (Canis familiaris)
        
        2x RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - RET tyrosine phosphorylation (Canis familiaris)
        
        2x RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - SHC1 in the RET complex is phosphorylated (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - p-5Y-RET complexes bind GRB2 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
      - p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
        
        RAS GEFs [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA:GDNF complexes [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2:GDNF,NRTN [plasma membrane] (Canis familiaris)
        
        p-5Y-RET:GFRA1,GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1, GFRA2 [plasma membrane] (Canis familiaris)
        
        GFRA1 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3QCB4

Gene Names

GFRA1

Reference Genes

BioGPS Gene:609114 GFRA1

ENSEMBL:ENSCAFG00845030969.1

KEGG:cfa:609114 GFRA1

Monarch:609114 GFRA1

NCBI Gene:609114 GFRA1

UCSC:A0A8I3QCB4 GFRA1

Reference Transcript

Other Identifiers

609114

Cfa.6080.1.A1_at

CfaAffx.18324.1.S1_at

GO:0005886

GO:0007169

GO:0007399

GO:0016020

GO:0016167

GO:0035860

GO:0038023

GO:0048856

GO:0098552

Participates

as an input of

RET binds GFRA1,GFRA3 (Canis familiaris)

as a component of

RET:GFRA1,GFRA3 [plasma membrane] (Canis familiaris)

as a member of

GFRA1, GFRA2 [plasma membrane] (Canis familiaris)

Inferred From

GFRA1,GFRA3 [plasma membrane] (Homo sapiens)

GFRA1 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_038434818.1, XP_038296612.1, XP_038316585.1, XP_038316586.1, XP_038296611.1, XP_038434817.1, XP_852087.1, XP_038296610.1, XP_038434819.1

ENSEMBL

ENSCAFT00845055039, ENSCAFG00845030969, ENSCAFP00845043276

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