Reactome | DOCK1 [cytosol]

DOCK1 [cytosol]

Stable Identifier

R-CFA-372654

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

DOCK1, A0A8I3S6D8

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - Netrin-1 signaling (Canis familiaris)
      - DCC mediated attractive signaling (Canis familiaris)
        
        Activation of Cdc42 (Canis familiaris)
        
        DOCK1 [cytosol] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1 [cytosol] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1 [cytosol] (Canis familiaris)
        
        Activation of Rac1 (Canis familiaris)
        
        DOCK1 [cytosol] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1 [cytosol] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1 [cytosol] (Canis familiaris)
        
        Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1 [cytosol] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1 [cytosol] (Canis familiaris)
        
        RhoGTPase GEF's recruited to DCC (Canis familiaris)
        
        DOCK1 [cytosol] (Canis familiaris)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
        
        DOCK1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S6D8

Gene Names

DOCK1

Reference Genes

ENSEMBL:ENSCAFG00845027604.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845027604.1 DOCK1

Other Identifiers

486934

Cfa.14167.1.A1_at

Cfa.15172.1.A1_at

CfaAffx.20305.1.S1_at

CfaAffx.20305.1.S1_s_at

GO:0002244

GO:0005085

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0007264

GO:0016477

GO:0016607

GO:0023052

GO:0030154

GO:0043226

GO:0048856

GO:0048870

GO:0098772

Participates

as a candidate of

as a member of

as a component of

as an input of

RhoGTPase GEF's recruited to DCC (Canis familiaris)

Inferred From

DOCK1,TRIO [cytosol] (Homo sapiens)

DOCK1 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000150760

Ensembl

ENSCAFT00845048707, ENSCAFP00845038213, ENSCAFG00845027604

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