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DOCK1 [cytosol]
Stable Identifier
R-CFA-372654
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
DOCK1, A0A8I3S6D8
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Canis familiaris)
Cell junction organization (Canis familiaris)
Cell-cell junction organization (Canis familiaris)
Adherens junctions interactions (Canis familiaris)
Activation of STAT3 by cadherin engagement (Canis familiaris)
SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) (Canis familiaris)
SRC promotes RAC1 and CDC42 activation by phosphorylating RAC1 and CDC42 GEFs (Canis familiaris)
SRC targeted RAC1/CDC42 GEFs [cytosol] (Canis familiaris)
SRC-targeted RAC1 GEFs [cytosol] (Canis familiaris)
DOCK1:ELMO1 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Developmental Biology (Canis familiaris)
Nervous system development (Canis familiaris)
Axon guidance (Canis familiaris)
Netrin-1 signaling (Canis familiaris)
DCC mediated attractive signaling (Canis familiaris)
Activation of Cdc42 (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Activation of Rac1 (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Recruitment and activation of N-WASP by Cdc42 (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
RhoGTPase GEF's recruited to DCC (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Hemostasis (Canis familiaris)
Factors involved in megakaryocyte development and platelet production (Canis familiaris)
DOCKs bind to RhoGEFs (Canis familiaris)
DOCK-GEFs [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
DOCK-GEFs:RAC1, CDC42 [cytosol] (Canis familiaris)
DOCK-GEFs [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Non-Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PTK6 (Canis familiaris)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Canis familiaris)
Activation of RAC1 by the PXN:CRK complex (Canis familiaris)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Phosphorylated PXN recruits the CRK complex (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by VEGF (Canis familiaris)
VEGFA-VEGFR2 Pathway (Canis familiaris)
DOCK180:ELMO binds CRK (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
RAC1 GTPase cycle (Canis familiaris)
RAC1 GEFs activate RAC1 (Canis familiaris)
RAC1 GEFs [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
RAC2 GTPase cycle (Canis familiaris)
RAC2 GEFs activate RAC2 (Canis familiaris)
RAC2 GEFs [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
RHOG GTPase cycle (Canis familiaris)
RHOG binds effectors at the plasma membrane (Canis familiaris)
RHOG plasma membrane effectors [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
RHOG:GTP:RHOG plasma membrane effectors [plasma membrane] (Canis familiaris)
RHOG plasma membrane effectors [cytosol] (Canis familiaris)
DOCK1 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3S6D8
Gene Names
DOCK1
Reference Genes
ENSEMBL:ENSCAFG00845027604.1
UCSC:A0A8I3S6D8 DOCK1
Other Identifiers
486934
Cfa.14167.1.A1_at
Cfa.15172.1.A1_at
CfaAffx.20305.1.S1_at
CfaAffx.20305.1.S1_s_at
GO:0002244
GO:0005085
GO:0005515
GO:0005737
GO:0007264
GO:0016020
GO:0016477
GO:0030154
GO:0048870
Participates
as a candidate of
RAC2 GEFs [cytosol] (Canis familiaris)
RAC1 GEFs [cytosol] (Canis familiaris)
as a member of
RHOG plasma membrane effectors [cytosol] (Canis familiaris)
DOCK-GEFs [cytosol] (Canis familiaris)
as a component of
DOCK1:ELMO1 [cytosol] (Canis familiaris)
NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Canis familiaris)
DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Canis familiaris)
as an input of
RhoGTPase GEF's recruited to DCC (Canis familiaris)
Other forms of this molecule
phospho-DOCK1 [cytosol]
Inferred From
DOCK1,TRIO [cytosol]
(Homo sapiens)
DOCK1 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFP00845038213
,
ENSCAFG00845027604
,
ENSCAFT00845048707
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