Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
VCL [cytosol]
Stable Identifier
R-CFA-350753
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
VCL, A0A8I3N7S1
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to mechanical stimuli (Canis familiaris)
Response of endothelial cells to shear stress (Canis familiaris)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Canis familiaris)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Canis familiaris)
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Response to elevated platelet cytosolic Ca2+ (Canis familiaris)
Platelet degranulation (Canis familiaris)
Release of platelet cytosolic components (Canis familiaris)
Platelet releasate cytosolic proteins [cytosol] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Muscle contraction (Canis familiaris)
Smooth Muscle Contraction (Canis familiaris)
ATP Hydrolysis By Myosin (Canis familiaris)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
integrin:cytoskeletal adhesion complex [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
integrin:cytoskeletal adhesion complex [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Calcium Binds Caldesmon (Canis familiaris)
Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
integrin:cytoskeletal adhesion complex [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Canis familiaris)
integrin:cytoskeletal adhesion complex [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Myosin Binds ATP (Canis familiaris)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
integrin:cytoskeletal adhesion complex [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
integrin:cytoskeletal adhesion complex [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Release Of ADP From Myosin (Canis familiaris)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
integrin:cytoskeletal adhesion complex [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Calcium Bound Myosin Actin Complex [plasma membrane] (Canis familiaris)
integrin:cytoskeletal adhesion complex [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
MAP2K and MAPK activation (Canis familiaris)
Dissociation of RAS:RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Dual mechanism MAPK inhibitors bind MAPKs (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
MAP2Ks and MAPKs bind to the activated RAF complex (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
MAP2Ks phosphorylate MAPKs (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
RAF phosphorylates MAP2K dimer (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Canis familiaris)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Canis familiaris)
RAF/MAPK scaffolds [cytosol] (Canis familiaris)
Focal Adhesion/Focal contacts [plasma membrane] (Canis familiaris)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
VCL [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N7S1
Gene Names
VCL
Reference Genes
ENSEMBL:ENSCAFG00845009183.1
UCSC:A0A8I3N7S1 VCL
Other Identifiers
Cfa.1684.1.S1_at
Cfa.1684.2.S1_s_at
Cfa.20266.1.S1_at
CfaAffx.23509.1.S1_s_at
GO:0002009
GO:0002102
GO:0002162
GO:0003779
GO:0005198
GO:0005737
GO:0005856
GO:0005886
GO:0005911
GO:0005912
GO:0005916
GO:0005925
GO:0007155
GO:0008092
GO:0015629
GO:0016020
GO:0030032
GO:0030334
GO:0031625
GO:0032991
GO:0034330
GO:0034333
GO:0034394
GO:0042383
GO:0043034
GO:0043226
GO:0043297
GO:0044291
GO:0045294
GO:0048675
GO:0051015
GO:0051893
GO:0061826
GO:0070161
GO:0090136
GO:1903140
GO:1904702
Participates
as a component of
integrin:cytoskeletal adhesion complex [plasma membrane] (Canis familiaris)
Vinculin bound to PIP2 [plasma membrane] (Canis familiaris)
as a member of
Platelet releasate cytosolic proteins [cytosol] (Canis familiaris)
as an input of
Calpain2 (m-Calpain, CAPN2:CAPNS:Ca2+) cleaves VCL (Vinculin) (Canis familiaris)
Other forms of this molecule
VCL [cytosol]
VCL [ficolin-1-rich granule lumen]
VCL [secretory granule lumen]
VCL [extracellular region]
VCL [specific granule lumen]
Inferred From
VCL [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
ENSCAFT00845016580
,
ENSCAFP00845012897
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
