Reactome | ITGB3BP [cytosol]

ITGB3BP [cytosol]

Stable Identifier

R-CFA-3006405

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

ITGB3BP, A0A8I3RSD6

Locations in the PathwayBrowser

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Cell Cycle (Canis familiaris)

- Cell Cycle Checkpoints (Canis familiaris)
  - Mitotic Spindle Checkpoint (Canis familiaris)
    - Amplification of signal from the kinetochores (Canis familiaris)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Canis familiaris)
        
        MAD2 associates with the Mad1 kinetochore complex (Canis familiaris)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Canis familiaris)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Mad1 binds kinetochore (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Release of activated MAD2 from kinetochores (Canis familiaris)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Mad1:kinetochore complex [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
- Cell Cycle, Mitotic (Canis familiaris)
  - M Phase (Canis familiaris)
    - Mitotic Metaphase and Anaphase (Canis familiaris)
      - Mitotic Anaphase (Canis familiaris)
        
        Separation of Sister Chromatids (Canis familiaris)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Canis familiaris)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Separation of sister chromatids (Canis familiaris)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
    - Mitotic Prometaphase (Canis familiaris)
      - EML4 and NUDC in mitotic spindle formation (Canis familiaris)
        
        EML4 recruits NUDC to mitotic spindle (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
      - Kinetochore capture of astral microtubules (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
      - Resolution of Sister Chromatid Cohesion (Canis familiaris)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Kinetochore assembly (Canis familiaris)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Canis familiaris)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Canis familiaris)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Canis familiaris)
        
        Microtubule-bound kinetochore [cytosol] (Canis familiaris)
        
        Kinetochore [cytosol] (Canis familiaris)
        
        CCAN network [cytosol] (Canis familiaris)
        
        CENP-O complex [cytosol] (Canis familiaris)
        
        ITGB3BP [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RSD6

Gene Names

ITGB3BP

Reference Genes

BioGPS Gene:609967 ITGB3BP

ENSEMBL:ENSCAFG00845004941.1

Monarch:609967 ITGB3BP

NCBI Gene:609967 ITGB3BP

UCSC:A0A8I3RSD6 ITGB3BP

Reference Transcript

Other Identifiers

609967

GO:0000775

GO:0000776

GO:0005634

GO:0006325

GO:0006355

GO:0034080

GO:0043226

GO:0050679

GO:1904036

Participates

as an input of

TRAF6 polyubiquitinates NRIF (Canis familiaris)

as an output of

gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Canis familiaris)

as a component of

Other forms of this molecule

ITGB3BP [nucleoplasm]

Inferred From

ITGB3BP [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038393228.1, XP_038521925.1, XP_038375539.1

ENSEMBL

ENSCAFP00845006978, ENSCAFT00845008856, ENSCAFG00845004941

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