Reactome | EFNB3 [plasma membrane]

EFNB3 [plasma membrane]

Stable Identifier

R-CFA-2682319

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

EFNB3, A0A8I3PTE3

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - EPH-Ephrin signaling (Canis familiaris)
      - EPH receptors autophosphorylate (Canis familiaris)
        
        EPH-ephrin oligomers [plasma membrane] (Canis familiaris)
        
        EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
      - EPH-ephrin mediated repulsion of cells (Canis familiaris)
        
        Clathrin internalises EPH:EFN complexes (Canis familiaris)
        
        EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        MMP2,9 cleave EPHB (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        SFKs phosphorylate VAV2,3 (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        VAV exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:p-VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        p-EPHs bind VAV2,3 (Canis familiaris)
        
        EFNAs/EFNBs:p-EPHAs/p-EPHBs:SFKs:VAV2,VAV3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers:SRC,FYN,YES1,LYN [plasma membrane] (Canis familiaris)
        
        p-EPH:ephrin oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
      - EPH:EFN dimers tetramerise (Canis familiaris)
        
        EPH-EFN dimers [plasma membrane] (Canis familiaris)
        
        EPHB:EFNB dimers [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
      - EPH:EFN tetramers oligomerise (Canis familiaris)
        
        EPH-EFN dimers [plasma membrane] (Canis familiaris)
        
        EPHB:EFNB dimers [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EPH-ephrin oligomers [plasma membrane] (Canis familiaris)
        
        EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EPHAs:EFNAs,EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
      - EPHB-mediated forward signaling (Canis familiaris)
        
        CDC42 and PIP2 bind WASL, activating it (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EPHB phosphorylates TIAM1 (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EPHB2 binds KALRN (Canis familiaris)
        
        EFNBs:p-EPHBs:KALRN [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EPHB:NMDAR binds TIAM1 (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        KALRN exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNBs:p-EPHBs:KALRN [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        N-WASP binds ARP2/3 and G-actin (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2 [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:ITSN1:N-WASP [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        Ras:GTP binds p120-RasGAP (Canis familiaris)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        Recruitment of p190RhoGEF to p-FAK (Canis familiaris)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        p-TIAM1 exchanges GTP for GDP on RAC1, activating it (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:SFKs [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        p120-RasGAP activates GTP hydrolysis on RAS, inactivating it (Canis familiaris)
        
        p-EPHBs:EFNBs:RASA1:HRAS:GDP [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:RASA1:HRAS:GTP [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs:RASA1 [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Canis familiaris)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Canis familiaris)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Canis familiaris)
        
        p-EPHB:EFNB oligomers [plasma membrane] (Canis familiaris)
        
        p-EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
      - EPHBs bind EFNBs (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
      - Ephrin signaling (Canis familiaris)
        
        EFNBs bind SDCBP (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs:SDCBP [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EFNBs bind SFKs (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs:SRC,FYN [plasma membrane] (Canis familiaris)
        
        EPHBs:EFNBs [plasma membrane] (Canis familiaris)
        
        EFNBs [plasma membrane] (Canis familiaris)
        
        EFNB3 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PTE3

Gene Names

EFNB3

Reference Genes

ENSEMBL:ENSCAFG00845024900.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845024900.1 EFNB3

Other Identifiers

607903

Cfa.15231.1.A1_at

CfaAffx.25578.1.S1_at

CfaAffx.25578.1.S1_s_at

GO:0002376

GO:0005886

GO:0007155

GO:0007411

GO:0007628

GO:0016020

GO:0016198

GO:0023052

GO:0030154

GO:0031295

GO:0042734

GO:0046875

GO:0048013

GO:0048856

GO:0050771

GO:0098686

GO:0098978

GO:0099557

Participates

as a member of

EFNBs [plasma membrane] (Canis familiaris)

Other forms of this molecule

phospho-EFNB3 [plasma membrane]

Inferred From

EFNB3 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000108947

Ensembl

ENSCAFG00845024900, ENSCAFT00845043959, ENSCAFP00845034448

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