Reactome | DNM1 [cytosol]

DNM1 [cytosol]

Stable Identifier

R-CFA-2213182

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

DNM1, A0A8I3PZW5

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DNM:GDP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DNM:GDP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
    - BAR domain proteins recruit dynamin (Canis familiaris)
      - DNM:GTP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        DNM:GTP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DNM:GDP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DNM:GDP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DNM:GDP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DNM:GDP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DNM:GDP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        DNM:GTP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        DNM:GTP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        DNM:GTP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DNM:GDP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DNM:GDP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        DNM:GDP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        DNM:GTP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Canis familiaris)
        
        DNM:GTP [cytosol] (Canis familiaris)
        
        Dynamin [cytosol] (Canis familiaris)
        
        DNM1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PZW5

Gene Names

DNM1

Reference Genes

BioGPS Gene:491319 DNM1

ENSEMBL:ENSCAFG00845029334.1

Monarch:491319 DNM1

NCBI Gene:491319 DNM1

UCSC:A0A8I3PZW5 DNM1

Reference Transcript

RefSeq:XM_038675063.1 DNM1

Other Identifiers

491319

Cfa.10966.1.A1_at

Cfa.17922.1.S1_at

Cfa.17922.1.S1_s_at

CfaAffx.30737.1.S1_s_at

GO:0000166

GO:0002376

GO:0003924

GO:0005525

GO:0005546

GO:0005547

GO:0005737

GO:0005874

GO:0005886

GO:0005905

GO:0006897

GO:0006898

GO:0007032

GO:0008017

GO:0008092

GO:0016020

GO:0016185

GO:0016192

GO:0016787

GO:0031410

GO:0042583

GO:0042802

GO:0042803

GO:0042995

GO:0045087

GO:0045202

GO:0051260

GO:0051289

GO:0051607

GO:0065003

GO:0098542

GO:0098793

GO:0099050

Participates

as a candidate of

Dynamin [cytosol] (Canis familiaris)

Other forms of this molecule

DNM1 [lysosomal membrane]

DNM1 [plasma membrane]

Inferred From

DNM1 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038530991.1

ENSEMBL

ENSCAFG00845029334, ENSCAFP00845040760, ENSCAFT00845051951

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