Reactome | COL5A1 [extracellular region]

COL5A1 [extracellular region]

Stable Identifier

R-CFA-2127371

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

extracellular region

Synonyms

3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain, A0A8I3NPB0

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - NCAM signaling for neurite out-growth (Canis familiaris)
      - NCAM1 interactions (Canis familiaris)
        
        Interaction of NCAM1 with collagens (Canis familiaris)
        
        Collagens [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        NCAM-1:Collagen complex [plasma membrane] (Canis familiaris)
        
        Collagens [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)

Extracellular matrix organization (Canis familiaris)

- Collagen formation (Canis familiaris)
  - Assembly of collagen fibrils and other multimeric structures (Canis familiaris)
    - Formation of collagen fibres (Canis familiaris)
      - Collagen fibres [extracellular region] (Canis familiaris)
        
        Collagen type V fibre [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
      - Collagen fibrils [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
    - Formation of collagen fibrils (Canis familiaris)
      - Collagen fibrils [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
      - Tropocollagens [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
  - Collagen biosynthesis and modifying enzymes (Canis familiaris)
    - Removal of fibrillar collagen C-propeptides (Canis familiaris)
      - Tropocollagens [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
- Degradation of the extracellular matrix (Canis familiaris)
  - Collagen degradation (Canis familiaris)
    - Collagen type V degradation by MMP2,9,10 (Canis familiaris)
      - Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
- ECM proteoglycans (Canis familiaris)
  - VTN binds collagens II, III and V (Canis familiaris)
    - Collagen types II, III, V [extracellular region] (Canis familiaris)
      - Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
    - VTN:Collagen types II,III,V [extracellular region] (Canis familiaris)
      - Collagen types II, III, V [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
- Fibronectin matrix formation (Canis familiaris)
  - FN1 binds Collagen types I-V, VII (Canis familiaris)
    - Collagen types I-V, VII [extracellular region] (Canis familiaris)
      - Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
    - FN1(32-2386):Collagen types I-V, VII [extracellular region] (Canis familiaris)
      - Collagen types I-V, VII [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
- Integrin cell surface interactions (Canis familiaris)
  - Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Canis familiaris)
    - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Canis familiaris)
      - Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
    - Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Canis familiaris)
      - Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
- Non-integrin membrane-ECM interactions (Canis familiaris)
  - DDR1 binds collagen type I, II, III, IV, V, XI fibrils (Canis familiaris)
    - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Canis familiaris)
      - Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
    - DDR1 dimer:Collagen type I, II, III, IV, V, XI fibrils [plasma membrane] (Canis familiaris)
      - Collagen type I, II, III, IV, V, XI fibrils [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
  - DDR2 binds collagen type I, II, III, V, X fibrils (Canis familiaris)
    - Collagen type I, II, III, V, X fibrils [extracellular region] (Canis familiaris)
      - Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
    - DDR2 dimer:Collagen type I, II, III, V, X fibrils [plasma membrane] (Canis familiaris)
      - Collagen type I, II, III, V, X fibrils [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by MET (Canis familiaris)
    - MET promotes cell motility (Canis familiaris)
      - MET activates PTK2 signaling (Canis familiaris)
        
        PTK2 binds activated MET (Canis familiaris)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Canis familiaris)
        
        Collagen, laminin, fibronectin [extracellular region] (Canis familiaris)
        
        Collagen fibres [extracellular region] (Canis familiaris)
        
        Collagen type V fibre [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
  - Signaling by PDGF (Canis familiaris)
    - PDGF binds to extracellular matrix proteins (Canis familiaris)
      - Extracellular matrix ligands [extracellular region] (Canis familiaris)
        
        Collagens [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
      - PDGF A and B chains:ECM complex [extracellular region] (Canis familiaris)
        
        Extracellular matrix ligands [extracellular region] (Canis familiaris)
        
        Collagens [extracellular region] (Canis familiaris)
        
        Collagen V [extracellular region] (Canis familiaris)
        
        Tropocollagen type V [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1(V)X2 alpha-2(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)
        
        Tropocollagen alpha-1-3(V) [extracellular region] (Canis familiaris)
        
        COL5A1 [extracellular region] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NPB0

Gene Names

COL5A1

Reference Genes

ENSEMBL:ENSCAFG00845012744.1

UCSC:A0A8I3NPB0 COL5A1

Other Identifiers

480684

Cfa.6322.1.S1_at

CfaAffx.30382.1.S1_s_at

CfaAffx.30396.1.S1_s_at

GO:0001568

GO:0003007

GO:0005198

GO:0005201

GO:0005581

GO:0005588

GO:0005604

GO:0007155

GO:0008201

GO:0016477

GO:0030198

GO:0030199

GO:0030312

GO:0031012

GO:0032964

GO:0035313

GO:0035989

GO:0043394

GO:0043588

GO:0045112

GO:0048407

GO:0048592

GO:0048856

GO:0048870

GO:0097435

GO:1903225

Participates

as a component of

Other forms of this molecule

COL5A1 [endoplasmic reticulum lumen]

COL5A1 [extracellular region]

Inferred From

Collagen alpha-1(V) chains [extracellular region] (Homo sapiens)

3,4-Hyp 5-Gal-Hyl collagen alpha-1(V) chain [extracellular region] (Homo sapiens)

Modified Residues

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,4R)-4-hydroxyproline at unknown position

PsiMod Name

(2S,4R)-4-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 4-hydroxy-L-proline

Name

(2S,3S)-3-hydroxyproline at unknown position

PsiMod Name

(2S,3S)-3-hydroxyproline

PsiMod Definition

A protein modification that effectively converts an L-proline residue to 3-hydroxy-L-proline.

Name

O5-galactosyl-L-hydroxylysine at unknown position

PsiMod Name

O5-galactosyl-L-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to O5-galactosyl-L-hydroxylysine.

Cross References

ENSEMBL

ENSCAFP00845018464, ENSCAFG00845012744, ENSCAFT00845023523

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