Reactome | phospho-FCGR2B [plasma membrane]

phospho-FCGR2B [plasma membrane]

Stable Identifier

R-CFA-2029069

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

p-Y288,Y304-FCGR2A, A0A8I3QQ00

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Canis familiaris)
    - Regulation of actin dynamics for phagocytic cup formation (Canis familiaris)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Canis familiaris)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
      - Activation of RAC1 by VAV (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
      - Phosphorylation of VAV (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Canis familiaris)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
      - Recruitment of VAV1 to p-6Y-SYK (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
    - Role of phospholipids in phagocytosis (Canis familiaris)
      - PI3K binds to p-6Y-SYK (Canis familiaris)
        
        PI3K:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
      - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        PI3K:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
      - Phosphorylation and activation of PLCG (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
      - Recruitment of PLCgamma to membrane (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
      - Release of PLCG from FCGR (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        clustered IgG-Ag:p-FCGRs [plasma membrane] (Canis familiaris)
        
        p-FCGRs [plasma membrane] (Canis familiaris)
        
        phospho-FCGR2B [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3QQ00

Gene Names

FCGR2B

Reference Genes

ENSEMBL:ENSCAFG00845028677.1

UCSC:A0A8I3QQ00 FCGR2B

Other Identifiers

100856270

CfaAffx.20171.1.S1_s_at

GO:0002682

GO:0005886

GO:0016020

GO:0019864

Participates

as a member of

p-FCGRs [plasma membrane] (Canis familiaris)

Other forms of this molecule

FCGR2B [secretory granule membrane]

FCGR2B [plasma membrane]

Inferred From

p-Y288,Y304-FCGR2A [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 288 (in Homo sapiens)

Coordinate

288

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 304 (in Homo sapiens)

Coordinate

304

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

ENSEMBL

ENSCAFP00845039716, ENSCAFG00845028677, ENSCAFT00845050663

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