Reactome | HLA-DRA [plasma membrane]

HLA-DRA [plasma membrane]

Stable Identifier

R-CFA-197588

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

HLA class II histocompatibility antigen, DR alpha chain precursor, A0A8I3S2N1

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - MHC class II antigen presentation (Canis familiaris)
    - Insertion of MHC II:Ii complex in to the plasma membrane (Canis familiaris)
      - MHC class II alpha/beta/Ii nonamer [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
    - Internalization of MHC II:Ii clathrin coated vesicle (Canis familiaris)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta/Ii nonamer [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
    - LAG3 (CD233) binds MHC II (Canis familiaris)
      - LAG3:MHC II [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
      - MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
    - Recruitment of clathrin coated vesicle by Ii (Canis familiaris)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta/Ii nonamer [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
      - MHC class II alpha/beta/Ii nonamer [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
    - Transport of antigen loaded MHC II molecules to surface (Canis familiaris)
      - MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
  - Regulation of T cell activation by CD28 family (Canis familiaris)
    - Co-inhibition by PD-1 (Canis familiaris)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
  - TCR signaling (Canis familiaris)
    - Downstream TCR signaling (Canis familiaris)
      - Change of PKC theta conformation (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
    - Generation of second messenger molecules (Canis familiaris)
      - Phosphorylation of PLC-gamma1 (Canis familiaris)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
      - Phosphorylation of SLP-76 (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
      - Phosphorylation of TBSMs in LAT (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
    - Phosphorylation of CD3 and TCR zeta chains (Canis familiaris)
      - Activation of Lck (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
      - Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
      - Inactivation of LCK by PTPN22 (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
      - Inactivation of Lck by Csk (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
      - Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
    - Translocation of ZAP-70 to Immunological synapse (Canis familiaris)
      - Activation of ZAP-70 (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
      - PTPN22 dephosphorylates ZAP70 (Canis familiaris)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
      - Phosphorylation of ZAP-70 by Lck (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
        
        phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II alpha/beta dimer [plasma membrane] (Canis familiaris)
        
        HLA II alpha chain [plasma membrane] (Canis familiaris)
        
        HLA-DRA [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S2N1

Gene Names

HLA-DRA

Reference Genes

ENSEMBL:ENSCAFG00845017467.1

UCSC:A0A8I3S2N1 HLA-DRA

Other Identifiers

481731

Cfa.6456.1.S1_at

CfaAffx.2126.1.S1_s_at

GO:0001772

GO:0001916

GO:0002250

GO:0002376

GO:0002469

GO:0002491

GO:0002503

GO:0002504

GO:0005764

GO:0005765

GO:0005886

GO:0006955

GO:0009986

GO:0016020

GO:0019882

GO:0019886

GO:0030247

GO:0031902

GO:0032831

GO:0042605

GO:0042608

GO:0042613

GO:0043382

GO:0045622

GO:0050877

GO:0050890

GO:2000516

Participates

as a member of

HLA II alpha chain [plasma membrane] (Canis familiaris)

Other forms of this molecule

HLA-DRA [lumenal side of endoplasmic reticulum membrane]

HLA-DRA [ER to Golgi transport vesicle membrane]

HLA-DRA [Golgi membrane]

HLA-DRA [trans-Golgi network membrane]

HLA-DRA [transport vesicle membrane]

HLA-DRA [clathrin-coated endocytic vesicle membrane]

HLA-DRA [endocytic vesicle membrane]

HLA-DRA [lysosomal membrane]

Inferred From

HLA class II histocompatibility antigen, DR alpha chain precursor [plasma membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSCAFT00845030976, ENSCAFG00845017467, ENSCAFP00845024273

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