Reactome | NCAM1 [plasma membrane]

NCAM1 [plasma membrane]

Stable Identifier

R-CFA-190987

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

NCAM1, A0A8I3MHC0

Locations in the PathwayBrowser

Expand all

Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - NCAM signaling for neurite out-growth (Canis familiaris)
      - NCAM1 interactions (Canis familiaris)
        
        Interaction of NCAM1 with collagens (Canis familiaris)
        
        NCAM-1:Collagen complex [plasma membrane] (Canis familiaris)
        
        NCAM1 [plasma membrane] (Canis familiaris)
        
        NCAM1 [plasma membrane] (Canis familiaris)
        
        NCAM1 binds to ATP (Canis familiaris)
        
        NCAM-1:ATP [plasma membrane] (Canis familiaris)
        
        NCAM1 [plasma membrane] (Canis familiaris)
        
        NCAM1 [plasma membrane] (Canis familiaris)
      - NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Canis familiaris)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        NCAM:pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        NCAM1:NCAM1 trans-homotetramer [plasma membrane] (Canis familiaris)
        
        NCAM1 cis-homodimer [plasma membrane] (Canis familiaris)
        
        NCAM1 [plasma membrane] (Canis familiaris)
      - Recruitment of Grb2 to pFAK:NCAM1 (Canis familiaris)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        NCAM:pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        NCAM1:NCAM1 trans-homotetramer [plasma membrane] (Canis familiaris)
        
        NCAM1 cis-homodimer [plasma membrane] (Canis familiaris)
        
        NCAM1 [plasma membrane] (Canis familiaris)
        
        Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        NCAM:pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        NCAM1:NCAM1 trans-homotetramer [plasma membrane] (Canis familiaris)
        
        NCAM1 cis-homodimer [plasma membrane] (Canis familiaris)
        
        NCAM1 [plasma membrane] (Canis familiaris)
      - SOS binds Grb2 bound to pFAK:NCAM1 (Canis familiaris)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        NCAM:pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        NCAM1:NCAM1 trans-homotetramer [plasma membrane] (Canis familiaris)
        
        NCAM1 cis-homodimer [plasma membrane] (Canis familiaris)
        
        NCAM1 [plasma membrane] (Canis familiaris)
        
        Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        NCAM:pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        NCAM1:NCAM1 trans-homotetramer [plasma membrane] (Canis familiaris)
        
        NCAM1 cis-homodimer [plasma membrane] (Canis familiaris)
        
        NCAM1 [plasma membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
        
        RAS GEFs [plasma membrane] (Canis familiaris)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Canis familiaris)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        NCAM:pFyn-Y420 [plasma membrane] (Canis familiaris)
        
        NCAM1:NCAM1 trans-homotetramer [plasma membrane] (Canis familiaris)
        
        NCAM1 cis-homodimer [plasma membrane] (Canis familiaris)
        
        NCAM1 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3MHC0

Gene Names

NCAM1

Reference Genes

ENSEMBL:ENSCAFG00845000915.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845000915.1 NCAM1

Other Identifiers

479435

Cfa.1581.1.S1_s_at

Cfa.1581.2.S1_s_at

CfaAffx.21405.1.S1_s_at

GO:0005515

GO:0005829

GO:0005886

GO:0007155

GO:0009897

GO:0009986

GO:0016020

Participates

as an input of

as a component of

Other forms of this molecule

NCAM1 [Golgi membrane]

Inferred From

NCAM1 [plasma membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000149294

Ensembl

ENSCAFP00845001361, ENSCAFT00845001721, ENSCAFG00845000915