Reactome | phospho-GAB1 [cytosol]

phospho-GAB1 [cytosol]

Stable Identifier

R-CFA-180344

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

p-5Y-GAB1, A0A8I3NXI8

Locations in the PathwayBrowser

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Developmental Biology (Canis familiaris)

- Nervous system development (Canis familiaris)
  - Axon guidance (Canis familiaris)
    - RET signaling (Canis familiaris)
      - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
      - p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Canis familiaris)
        
        p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - Negative regulation of the PI3K/AKT network (Canis familiaris)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
        
        PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        Activator:PI3K [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
    - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - Activator:PI3K [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by EGFR (Canis familiaris)
    - GAB1 signalosome (Canis familiaris)
      - Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
      - Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
      - Dephosphorylation of PAG by SHP2 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
      - GAB1 phosphorylation by EGFR kinase (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
      - PI3K binds to EGF:EGFR:GRB2:GAB1 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
      - PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
      - SHP2 dephosphorylates Tyr 992 on EGFR (Canis familiaris)
        
        EGF-like ligands:p-5Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
      - Sustained activation of SRC kinase by SHP2 (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Canis familiaris)
        
        EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        GRB2:p-5Y-GAB1,GRB2:p-5Y-GAB1:PIP3 [cytosol] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GRB2:p-5Y-GAB1:PIP3 [plasma membrane] (Canis familiaris)
        
        GRB2:Phospho-GAB1 [cytosol] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
  - Signaling by MET (Canis familiaris)
    - MET activates PI3K/AKT signaling (Canis familiaris)
      - MET bound PI3K generates PIP3 (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
      - MET phosphorylates GAB1 (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
      - Phosphorylated GAB1 recruits PI3K to MET (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
    - MET activates PTPN11 (Canis familiaris)
      - GAB1 binds PTPN11 (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PTPN11 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
    - MET promotes cell motility (Canis familiaris)
      - MET activates RAP1 and RAC1 (Canis familiaris)
        
        CRK,CRKL recruits RAC1 GEF to activated MET (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        DOCK7 activates RAC1 (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:(DOCK7) [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        GAB1 recruits CRK,CRKL to MET (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        RAPGEF1 activates RAP1 (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        RAPGEF1 binds CRK,CRKL (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:RAPGEF1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
    - MET receptor recycling (Canis familiaris)
      - GGA3 associates with activated MET receptor (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
      - RAB4:GTP promotes recycling of activated MET receptor to the plasma membrane (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL:GGA3:ARF6:GTP [recycling endosome membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:CRK,CRKL [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:GRB2-1:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)
        
        HGF:p-4Y-MET dimer:p-5Y-GAB1 [plasma membrane] (Canis familiaris)
        
        phospho-GAB1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NXI8

Gene Names

GAB1

Reference Genes

BioGPS Gene:483808 GAB1

ENSEMBL:ENSCAFG00845018786.1

Monarch:483808 GAB1

NCBI Gene:483808 GAB1

UCSC:A0A8I3NXI8 GAB1

Reference Transcript

Other Identifiers

483808

Cfa.1615.1.S1_at

Cfa.19271.1.S1_s_at

Cfa.19430.1.S1_at

CfaAffx.6359.1.S1_s_at

GO:0001525

GO:0005911

GO:0007165

GO:0035767

GO:0038084

GO:0045766

GO:0048870

Participates

as a member of

p-5Y-GAB1,p-5Y-GAB2 [cytosol] (Canis familiaris)

as a component of

Other forms of this molecule

phospho-GAB1 [cytosol]

GAB1 [cytosol]

Inferred From

p-5Y-GAB1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 627 (in Homo sapiens)

Coordinate

627

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 659 (in Homo sapiens)

Coordinate

659

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 447 (in Homo sapiens)

Coordinate

447

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 472 (in Homo sapiens)

Coordinate

472

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 589 (in Homo sapiens)

Coordinate

589

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_038281572.1, XP_038420470.1, XP_038310505.1

ENSEMBL

ENSCAFG00845018786, ENSCAFP00845026075, ENSCAFT00845033313

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