Reactome | CD80 [plasma membrane]

CD80 [plasma membrane]

Stable Identifier

R-CFA-179789

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

CD80, Q9TQX1

Locations in the PathwayBrowser

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Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Regulation of T cell activation by CD28 family (Canis familiaris)
    - Co-inhibition by CTLA4 (Canis familiaris)
      - CTLA-4 binds B7-1/B7-2 (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
      - Phosphorylation of CTLA-4 (Canis familiaris)
        
        PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Canis familiaris)
        
        p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
      - SHP2 phosphatase binds CTLA-4 (Canis familiaris)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Canis familiaris)
        
        p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        pCTLA-4:Src kinases:SHP2 [plasma membrane] (Canis familiaris)
        
        p-Y201,Y218-CTLA-4 dimer:SFKs [plasma membrane] (Canis familiaris)
        
        p-Y201,Y218-CTLA4 dimer:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
    - Co-stimulation by CD28 (Canis familiaris)
      - CD28 dependent PI3K/Akt signaling (Canis familiaris)
        
        CD28 bound PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        CD28:PI3K [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        PI3K binds CD28 (Canis familiaris)
        
        CD28:PI3K [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
      - CD28 dependent Vav1 pathway (Canis familiaris)
        
        Activation of Cdc42 by pVav1 (Canis familiaris)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        Activation of Rac1 by pVav1 (Canis familiaris)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        Activation of Vav1 (Canis familiaris)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        p-Y142,160,174-VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        Grb2 binds CD28 (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        Translocation of Vav1 to CD28 (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        VAV1:PIP3:CD28:GRB2 [plasma membrane] (Canis familiaris)
        
        CD28:Grb2 [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
      - CD28 homodimer binds B7-1 homodimer (Canis familiaris)
        
        CD28:B7-1 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
      - CD28 homodimer binds B7-2 monomer (Canis familiaris)
        
        PP2A:CTLA4:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
      - Gads binds CD28 (Canis familiaris)
        
        CD28:GRAP2 [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
      - Phosphorylation of CD28 (Canis familiaris)
        
        CD28:B7-1,B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - Negative regulation of the PI3K/AKT network (Canis familiaris)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
        
        PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        Activator:PI3K [plasma membrane] (Canis familiaris)
        
        CD28:PI3K [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)
    - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - Activator:PI3K [plasma membrane] (Canis familiaris)
        
        CD28:PI3K [plasma membrane] (Canis familiaris)
        
        phospho CD28:B7-1/B7-2 [plasma membrane] (Canis familiaris)
        
        B7-1 homodimer/ B7-2 [plasma membrane] (Canis familiaris)
        
        CD80 dimer [plasma membrane] (Canis familiaris)
        
        CD80 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:Q9TQX1

Gene Names

CD80

Reference Genes

BioGPS Gene:403765 CD80

ENSEMBL:ENSCAFG00845016834.1

KEGG:cfa:403765 CD80

Monarch:403765 CD80

NCBI Gene:403765 CD80

UCSC:Q9TQX1 CD80

Reference Transcript

Other Identifiers

403765

Cfa.3596.2.S1_at

Cfa.3596.2.S1_s_at

CfaAffx.17176.1.S1_s_at

GO:0002376

GO:0002682

GO:0002710

GO:0005886

GO:0007165

GO:0015026

GO:0016020

GO:0031295

GO:0042110

GO:0048018

GO:0098636

GO:0098772

Participates

as a component of

CD80 dimer [plasma membrane] (Canis familiaris)

Inferred From

CD80 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_038300495.1, NP_001003147.1, XP_038300494.1, XP_038300496.1

ENSEMBL

ENSCAFP00845023436, ENSCAFG00845016834, ENSCAFT00845029840

VGNC

38975

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