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phospho-NFKBIA [cytosol]
Stable Identifier
R-CFA-177677
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-S32,S36-NFKBIA, A0A8I3MKL4
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
Activated IKK phosphorylates I-kappaB (Canis familiaris)
NF-kappaB p65:p65:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)
NF-kappaB p65:p65:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Canis familiaris)
NF-kappaB p65:p65:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Canis familiaris)
NF-kappaB p65:p65:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Cytosolic sensors of pathogen-associated DNA (Canis familiaris)
ZBP1(DAI) mediated induction of type I IFNs (Canis familiaris)
RIP-mediated NFkB activation via ZBP1 (Canis familiaris)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Canis familiaris)
TRAF6 mediated NF-kB activation (Canis familiaris)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
NF-kB is activated and signals survival (Canis familiaris)
IkB is ubiquitinated and degraded (Canis familiaris)
Ubiquitinated phospho-IkB [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MKL4
Gene Names
NFKBIA
Reference Genes
BioGPS Gene:480291 NFKBIA
ENSEMBL:ENSCAFG00845002047.1
KEGG:cfa:480291 NFKBIA
Monarch:480291 NFKBIA
NCBI Gene:480291 NFKBIA
UCSC:A0A8I3MKL4 NFKBIA
Reference Transcript
RefSeq:XM_038544496.1 NFKBIA
RefSeq:XM_038673428.1 NFKBIA
RefSeq:XM_537413.7 NFKBIA
Other Identifiers
480291
Cfa.12441.1.S1_s_at
GO:0000122
GO:0002376
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006355
GO:0006357
GO:0006606
GO:0006886
GO:0006913
GO:0006954
GO:0007219
GO:0007249
GO:0008139
GO:0010468
GO:0010745
GO:0010888
GO:0019899
GO:0023019
GO:0031625
GO:0031663
GO:0032375
GO:0032495
GO:0032496
GO:0033209
GO:0033256
GO:0034142
GO:0035994
GO:0038061
GO:0042127
GO:0042308
GO:0042802
GO:0043124
GO:0043330
GO:0045638
GO:0045746
GO:0045893
GO:0045944
GO:0050729
GO:0050853
GO:0051059
GO:0060261
GO:0070427
GO:0070431
GO:0070498
GO:0071345
GO:0071356
GO:0140311
GO:0140416
GO:1900016
Participates
as a member of
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
as an input of
IkB is ubiquitinated and degraded (Canis familiaris)
as a component of
Ubiquitinated phospho-IkB [cytosol] (Canis familiaris)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Canis familiaris)
as an output of
IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)
Other forms of this molecule
NFKBIA [cytosol]
NFKBIA [nucleoplasm]
NFKBIA [cytosol]
Inferred From
p-S32,S36-NFKBIA [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 32 (in Homo sapiens)
Coordinate
32
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 36 (in Homo sapiens)
Coordinate
36
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_038400424.1
,
XP_537413.3
,
XP_038529356.1
ENSEMBL
ENSCAFG00845002047
,
ENSCAFT00845003571
,
ENSCAFP00845002834
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