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phospho-NFKBIA [cytosol]
Stable Identifier
R-CFA-177677
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-S32,S36-NFKBIA, A0A8I3MKL4
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Downstream signaling events of B Cell Receptor (BCR) (Canis familiaris)
Activation of NF-kappaB in B cells (Canis familiaris)
Activated IKK phosphorylates I-kappaB (Canis familiaris)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Canis familiaris)
NF-KappaB p50:p50:p-IKBA [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB p50:p65:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB p65:p65:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB (Canis familiaris)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Canis familiaris)
NF-KappaB p50:p50:p-IKBA [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB p50:p65:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB p65:p65:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Canis familiaris)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Canis familiaris)
NF-KappaB p50:p50:p-IKBA [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB p50:p65:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB p65:p65:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
SCF-beta-TrCP ubiquitinylates IkB (Canis familiaris)
NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] (Canis familiaris)
NF-kappa-B p50,p65,c-Rel:p-IKB [cytosol] (Canis familiaris)
NF-KappaB p50:p50:p-IKBA [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB p50:c-Rel:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB p50:p65:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NF-kappaB p65:p65:p-IKB [cytosol] (Canis familiaris)
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
TCR signaling (Canis familiaris)
Downstream TCR signaling (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex (Canis familiaris)
BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Canis familiaris)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Canis familiaris)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex (Canis familiaris)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] (Canis familiaris)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex (Canis familiaris)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Cytosolic sensors of pathogen-associated DNA (Canis familiaris)
ZBP1(DAI) mediated induction of type I IFNs (Canis familiaris)
RIP-mediated NFkB activation via ZBP1 (Canis familiaris)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Canis familiaris)
TRAF6 mediated NF-kB activation (Canis familiaris)
Active IKK Complex phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated NF-kB activation (Canis familiaris)
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
Active IKBKB phosphorylates NF-kappa-B inhibitor (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Death Receptor Signaling (Canis familiaris)
p75 NTR receptor-mediated signalling (Canis familiaris)
p75NTR signals via NF-kB (Canis familiaris)
NF-kB is activated and signals survival (Canis familiaris)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
IkB is ubiquitinated and degraded (Canis familiaris)
Ubiquitinated phospho-IkB [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
phospho-NFKBIA [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MKL4
Gene Names
NFKBIA
Reference Genes
BioGPS Gene:480291 NFKBIA
ENSEMBL:ENSCAFG00845002047.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845002047.1 NFKBIA
KEGG Gene (Canis lupus familiaris):480291 NFKBIA
Monarch:480291 NFKBIA
NCBI Gene:480291 NFKBIA
Reference Transcript
RefSeq:XM_537413.5 NFKBIA
Other Identifiers
480291
Cfa.12441.1.S1_s_at
GO:0002376
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006606
GO:0006886
GO:0006913
GO:0006954
GO:0007219
GO:0007249
GO:0008139
GO:0010468
GO:0010745
GO:0010875
GO:0010888
GO:0019899
GO:0023052
GO:0030154
GO:0031625
GO:0031663
GO:0032495
GO:0032496
GO:0033209
GO:0034142
GO:0035994
GO:0038061
GO:0042127
GO:0042802
GO:0043124
GO:0043226
GO:0043330
GO:0045638
GO:0045746
GO:0045893
GO:0045944
GO:0048856
GO:0050729
GO:0050853
GO:0051059
GO:0051247
GO:0060261
GO:0070427
GO:0070431
GO:0070498
GO:0071356
GO:0098542
GO:0140311
GO:0140313
Participates
as a component of
NF-KappaB p50:p50:p-IKBA [cytosol] (Canis familiaris)
Ubiquitinated phospho-IkB [cytosol] (Canis familiaris)
NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] (Canis familiaris)
NFKB1(1-433):RELA:p-S32,S36-NFKBIA [cytosol] (Canis familiaris)
p-S32,36-IkB-alpha:NF-kB complex [cytosol] (Canis familiaris)
as a member of
p-IKB alpha,beta,epsilon [cytosol] (Canis familiaris)
Phospho-NF-kappaB Inhibitor [cytosol] (Canis familiaris)
as an input of
IkB is ubiquitinated and degraded (Canis familiaris)
as an output of
IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Canis familiaris)
Other forms of this molecule
NFKBIA [cytosol]
NFKBIA [nucleoplasm]
phospho-NFKBIA [cytosol]
NFKBIA [cytosol]
Inferred From
p-S32,S36-NFKBIA [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 32 (in Homo sapiens)
Coordinate
32
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 36 (in Homo sapiens)
Coordinate
36
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_537413.3
OpenTargets
ENSG00000100906
Ensembl
ENSCAFT00845003571
,
ENSCAFG00845002047
,
ENSCAFP00845002834
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