Reactome | ANAPC7 [cytosol]

ANAPC7 [cytosol]

Stable Identifier

R-CFA-174242

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

ANAPC7, A0A8I3S6H6

Locations in the PathwayBrowser

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Cell Cycle (Canis familiaris)

- Cell Cycle Checkpoints (Canis familiaris)
  - Mitotic Spindle Checkpoint (Canis familiaris)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Canis familiaris)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Canis familiaris)
        
        Binding of the MCC complex to the APC/C complex (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
- Cell Cycle, Mitotic (Canis familiaris)
  - M Phase (Canis familiaris)
    - Mitotic Metaphase and Anaphase (Canis familiaris)
      - Mitotic Anaphase (Canis familiaris)
        
        Separation of Sister Chromatids (Canis familiaris)
        
        Association of Securin with Cdc20:APC/C complex (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Degradation of multiubiquitinated Securin (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Canis familiaris)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
  - Regulation of mitotic cell cycle (Canis familiaris)
    - APC/C-mediated degradation of cell cycle proteins (Canis familiaris)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Canis familiaris)
        
        Association of cell cycle proteins with the APC/C:Cdh1 complex (Canis familiaris)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Degradation of multiubiquitinated cell cycle proteins (Canis familiaris)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex (Canis familiaris)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        multiubiquitinated cell cycle protein:APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        cell cycle proteins:phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
        
        APC/C:Cdc20 mediated degradation of Cyclin B (Canis familiaris)
        
        Association of Cyclin B:Cdc2 with Cdc20:APC/C complex (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Degradation of multiubiquitinated Cyclin B (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Canis familiaris)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex (Canis familiaris)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        multiubiquitinated Cyclin B:Cdc2:Cdc20:phospho-APC/C complex [cytosol] (Canis familiaris)
        
        Cdc20:phospho-APC/C:Cyclin B:Cdc2 complex [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        APC/C:Cdc20 mediated degradation of Securin (Canis familiaris)
        
        Association of Securin with Cdc20:APC/C complex (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Degradation of multiubiquitinated Securin (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Ubiquitination of Securin by phospho-APC/C:Cdc20 complex (Canis familiaris)
        
        CDC20:p-APC/C:PTTG1 [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        CDC20:pAPC/C:K11polyUb-PTTG1 [cytosol] (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Canis familiaris)
        
        APC-Cdc20 mediated degradation of Nek2A (Canis familiaris)
        
        Association of Nek2A with MCC:APC/C (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Nek2A:MCC:APC/C complex [cytosol] (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Degradation of multiubiquitinated Nek2A (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Multiubiquitinated Nek2A [cytosol] (Canis familiaris)
        
        Nek2A:MCC:APC/C complex [cytosol] (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Multiubiquitination of Nek2A (Canis familiaris)
        
        Multiubiquitinated Nek2A [cytosol] (Canis familiaris)
        
        Nek2A:MCC:APC/C complex [cytosol] (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Nek2A:MCC:APC/C complex [cytosol] (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Canis familiaris)
        
        Association of Cyclin A with the APC/C (Canis familiaris)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Degradation multiubiquitinated Cyclin A (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Canis familiaris)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Canis familiaris)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Canis familiaris)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
      - Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Canis familiaris)
        
        Association of Cdh1 with the APC/C (Canis familiaris)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        Dissociation of Cdc20 from APC/C complex (Canis familiaris)
        
        CDC20:p-APC/C [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
      - Regulation of APC/C activators between G1/S and early anaphase (Canis familiaris)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Canis familiaris)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Canis familiaris)
        
        Binding of the MCC complex to the APC/C complex (Canis familiaris)
        
        MCC:APC/C complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)
  - S Phase (Canis familiaris)
    - Synthesis of DNA (Canis familiaris)
      - Switching of origins to a post-replicative state (Canis familiaris)
        
        CDK-mediated phosphorylation and removal of Cdc6 (Canis familiaris)
        
        Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex (Canis familiaris)
        
        phospho-APC/C:Cdh1 complex [cytosol] (Canis familiaris)
        
        phosphorylated anaphase promoting complex (APC/C) [cytosol] (Canis familiaris)
        
        ANAPC7 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S6H6

Gene Names

ANAPC7

Reference Genes

BioGPS Gene:486264 ANAPC7

ENSEMBL:ENSCAFG00845027864.1

Monarch:486264 ANAPC7

NCBI Gene:486264 ANAPC7

UCSC:A0A8I3S6H6 ANAPC7

Reference Transcript

Other Identifiers

486264

Cfa.2879.1.A1_at

CfaAffx.13388.1.S1_at

GO:0000792

GO:0005515

GO:0005634

GO:0005654

GO:0005680

GO:0005737

GO:0005819

GO:0005856

GO:0007420

GO:0015630

GO:0016567

GO:0019903

GO:0030163

GO:0031145

GO:0043226

GO:0045171

GO:0045842

GO:0048856

GO:0051301

GO:0060090

GO:0070936

GO:0070979

GO:0072686

GO:0140767

GO:0141198

Participates

as a component of

Other forms of this molecule

ANAPC7 [nucleoplasm]

Inferred From

ANAPC7 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_038292550.1, XP_543390.4, XP_038430966.1

ENSEMBL

ENSCAFT00845049178, ENSCAFG00845027864, ENSCAFP00845038589

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