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CFB [plasma membrane]
Stable Identifier
R-CFA-173746
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
CFB(260-764), A0A8I3NLH3
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Complement cascade (Canis familiaris)
Activation of C3 and C5 (Canis familiaris)
Activation of C5 (Canis familiaris)
C5 convertases [plasma membrane] (Canis familiaris)
C3b:Bb:C3b:Properdin [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Cleavage of C3 by C3 convertases (Canis familiaris)
C3 convertases [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Initial triggering of complement (Canis familiaris)
Alternative complement activation (Canis familiaris)
Factor D cleaves C3b-bound Factor B (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Formation of alternative pathway C5 convertase (Canis familiaris)
C3b:Bb:C3b:Properdin [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Properdin stabilizes C3b:Bb bound to cell surfaces (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Regulation of Complement cascade (Canis familiaris)
C3 convertases spontaneously dissociate (Canis familiaris)
C3 convertases [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
CD55 (DAF) binds C3bBb, C4bC2a (Canis familiaris)
C4bC2a, C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
CD55:C3 convertase complexes [plasma membrane] (Canis familiaris)
CD55:C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
CD55 (DAF) promotes C3bBb/C4bC2a dissociation (Canis familiaris)
CD55:C3 convertase complexes [plasma membrane] (Canis familiaris)
CD55:C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
CR1 binds C3bBb/C4bC2a (Canis familiaris)
C4bC2a, C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Canis familiaris)
CR1:C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Displacement of C2a/Bb by CR1 (Canis familiaris)
CR1:C3bBb, C4bC2a complexes [plasma membrane] (Canis familiaris)
CR1:C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Factor H binds to C3bBb (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
Factor H displaces Bb (Canis familiaris)
Cell surface:CFH, CFHR3:C3bBb [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
CFB [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NLH3
Gene Names
CFB
Reference Genes
ENSEMBL:ENSCAFG00845013817.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845013817.1 CFB
Other Identifiers
100688056
Cfa.5944.1.A1_at
Cfa.6458.1.A1_s_at
Cfa.8846.1.A1_s_at
GO:0002376
GO:0003824
GO:0004252
GO:0005576
GO:0006508
GO:0006956
GO:0006958
GO:0008233
GO:0008236
GO:0016787
GO:0045087
GO:0098542
GO:0140096
Participates
as a component of
Cell surface:C3b:Bb:Properdin [plasma membrane] (Canis familiaris)
Cell surface:C3b:Bb [plasma membrane] (Canis familiaris)
Other forms of this molecule
CFB [extracellular region]
CFB [extracellular region]
CFB [extracellular region]
Inferred From
CFB(260-764) [plasma membrane]
(Homo sapiens)
Cross References
OpenTargets
ENSG00000243649
Ensembl
ENSCAFG00845013817
,
ENSCAFT00845024659
,
ENSCAFP00845019404
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