Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-Madh3 [cytosol]
Stable Identifier
R-CFA-171184
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
p-S423,S425-SMAD3, D2YYC0
Locations in the PathwayBrowser
Expand all
Developmental Biology (Canis familiaris)
Signaling by NODAL (Canis familiaris)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
Gene expression (Transcription) (Canis familiaris)
RNA Polymerase II Transcription (Canis familiaris)
Generic Transcription Pathway (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
WWTR1:SMAD translocates to the nucleus (Canis familiaris)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-37 signaling (Canis familiaris)
IL37(?-218) binds p-S423,S425-SMAD3 (Canis familiaris)
IL37(?-218):p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
IL37(?-218):p-S423,S425-SMAD3 translocates to the nucleus (Canis familiaris)
IL37(?-218):p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by Activin (Canis familiaris)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
Phosphorylation of SMAD2,3 by Activin:Activin Receptor (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
Downregulation of TGF-beta receptor signaling (Canis familiaris)
MTMR4 binds phosphorylated SMAD2/3 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
MTMR4 dephosphorylates SMAD2/3 (Canis familiaris)
p-2S-SMAD2/3:MTMR4 [early endosome membrane] (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
PMEPA1 sequesters phosphorylated SMAD2/3 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD2/3:PMEPA1 [early endosome membrane] (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
Phosphorylated SMAD2/3 dissociates from TGFBR (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Canis familiaris)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Canis familiaris)
Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4 (Canis familiaris)
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
WWTR1 binds SMAD2/3:SMAD4 heterotrimer (Canis familiaris)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
WWTR1:SMAD translocates to the nucleus (Canis familiaris)
WWTR1:p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2,3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
phospho-Madh3 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:D2YYC0
Gene Names
Madh3
Reference Genes
BioGPS Gene:610902 Madh3
ENSEMBL:ENSCAFG00845016639.1
KEGG:cfa:610902 Madh3
Monarch:610902 Madh3
NCBI Gene:610902 Madh3
UCSC:D2YYC0 Madh3
Reference Transcript
RefSeq:NM_001170829.3 Madh3
Other Identifiers
610902
CfaAffx.26604.1.S1_s_at
CfaAffx.26632.1.S1_s_at
GO:0000122
GO:0000165
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001217
GO:0001222
GO:0001223
GO:0001228
GO:0001501
GO:0001649
GO:0001657
GO:0001666
GO:0001701
GO:0001707
GO:0001756
GO:0001889
GO:0001947
GO:0002076
GO:0002376
GO:0002520
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0005160
GO:0005515
GO:0005518
GO:0005634
GO:0005637
GO:0005654
GO:0005667
GO:0005737
GO:0005815
GO:0005829
GO:0005886
GO:0006355
GO:0006357
GO:0006915
GO:0006955
GO:0007179
GO:0007254
GO:0007369
GO:0007492
GO:0008270
GO:0008283
GO:0008285
GO:0009880
GO:0010628
GO:0010629
GO:0010718
GO:0016202
GO:0016922
GO:0017015
GO:0017151
GO:0019901
GO:0019902
GO:0030154
GO:0030163
GO:0030279
GO:0030308
GO:0030878
GO:0031490
GO:0031625
GO:0031962
GO:0032332
GO:0032502
GO:0032810
GO:0032909
GO:0032924
GO:0033689
GO:0034330
GO:0035259
GO:0036064
GO:0038092
GO:0042110
GO:0042802
GO:0042803
GO:0043130
GO:0043161
GO:0043235
GO:0043425
GO:0043565
GO:0045216
GO:0045429
GO:0045599
GO:0045668
GO:0045893
GO:0045944
GO:0046872
GO:0048340
GO:0048589
GO:0048617
GO:0048701
GO:0048856
GO:0048870
GO:0050678
GO:0050728
GO:0050776
GO:0051481
GO:0060039
GO:0060391
GO:0060395
GO:0061045
GO:0061450
GO:0061629
GO:0070306
GO:0070410
GO:0070412
GO:0071141
GO:0071144
GO:0071559
GO:0071560
GO:0097190
GO:0097191
GO:0098586
GO:0140297
GO:1901203
GO:1902894
GO:1902895
GO:1990776
GO:1990841
Participates
as an input of
IL37(?-218) binds p-S423,S425-SMAD3 (Canis familiaris)
as a component of
IL37(?-218):p-S423,S425-SMAD3 [cytosol] (Canis familiaris)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [cytosol] (Canis familiaris)
as a member of
p-2S-SMAD2,3 [cytosol] (Canis familiaris)
Other forms of this molecule
Madh3 [cytosol]
phospho-Madh3 [cytosol]
Madh3 [nucleoplasm]
phospho-Madh3 [nucleoplasm]
phospho-Madh3 [nucleoplasm]
phospho-Madh3 [nucleoplasm]
Madh3 [cytosol]
phospho-Madh3 [nucleoplasm]
Inferred From
p-S423,S425-SMAD3 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 423 (in Homo sapiens)
Coordinate
423
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 425 (in Homo sapiens)
Coordinate
425
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001164300.3
ENSEMBL
ENSCAFG00845016639
,
ENSCAFT00845029611
,
ENSCAFP00845023256
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text