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TGFBR2 [plasma membrane]
Stable Identifier
R-CFA-170842
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
TGFBR2, A0A8I3S3B8
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by TGF-beta Receptor Complex (Canis familiaris)
TGF-beta receptor signaling activates SMADs (Canis familiaris)
Activated type I receptor phosphorylates SMAD2/3 directly (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
CBL binds TGFBR2 (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2:CBL [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
CBL neddylates TGFBR2 (Canis familiaris)
TGFBR2:CBL [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
Dimeric TGF-beta-1 binds to the receptor (Canis familiaris)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
Downregulation of TGF-beta receptor signaling (Canis familiaris)
BAMBI interferes with the interaction of type I receptor with type II receptor (Canis familiaris)
TGFB1: TGFBR2: p-TGFBR1: BAMBI: SMAD7 [plasma membrane] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
Degradation of TGF-beta receptor complex (Canis familiaris)
TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-SMAD7 [plasma membrane] (Canis familiaris)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
I-SMAD competes with SMAD2/3 for type I receptor (TGFBR1) (Canis familiaris)
TGFB1: p-TGFBR: I-SMAD7 [plasma membrane] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
STRAP stabilizes interaction of activated TGF-beta receptor complex with SMAD7 (Canis familiaris)
TGFB1: p-TGFBR: STRAP: SMAD7 [plasma membrane] (Canis familiaris)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFB1:p-TGFBR:STRAP [plasma membrane] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
Phosphorylated SMAD2/3 dissociates from TGFBR (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 phosphorylates TGFBR1 (Canis familiaris)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 recruits TGFBR1 (Canis familiaris)
Dimeric TGFB1:TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Canis familiaris)
Disassembly of tight junctions (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
SMURF1 binds phosphorylated PARD6A (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
SMURF1 ubiquitinates RHOA (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Canis familiaris)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Canis familiaris)
TGFB1:TGFBR2:p-TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
Signaling by TGFBR3 (Canis familiaris)
TGFBR3 regulates TGF-beta signaling (Canis familiaris)
Endocytosis of TGFBR3:ARRB complex (Canis familiaris)
pTGFBR3-complex:ARBB_endo [endocytic vesicle membrane] (Canis familiaris)
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
pTGFBR3-complex:ARRB [plasma membrane] (Canis familiaris)
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR3 binding to ARRB1/2 (Canis familiaris)
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
pTGFBR3-complex:ARRB [plasma membrane] (Canis familiaris)
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR3 complex binds to TGFBR2 (Canis familiaris)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR3 phosphorylation by TGFBR2 complex (Canis familiaris)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFB1:TGFBR2:TGFBR1 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3S3B8
Gene Names
TGFBR2
Reference Genes
BioGPS Gene:477039 TGFBR2
ENSEMBL:ENSCAFG00845022794.1
Monarch:477039 TGFBR2
NCBI Gene:477039 TGFBR2
UCSC:A0A8I3S3B8 TGFBR2
Reference Transcript
RefSeq:XM_038570626.1 TGFBR2
RefSeq:XM_038432085.1 TGFBR2
RefSeq:XM_038457142.1 TGFBR2
Other Identifiers
477039
Cfa.11234.1.A1_at
Cfa.12148.1.A1_at
Cfa.12651.1.A1_s_at
Cfa.128.1.S1_s_at
CfaAffx.9108.1.S1_at
GO:0000166
GO:0001569
GO:0001570
GO:0001701
GO:0001837
GO:0001947
GO:0002053
GO:0002088
GO:0002376
GO:0002651
GO:0002663
GO:0002666
GO:0003148
GO:0003149
GO:0003151
GO:0003180
GO:0003181
GO:0003186
GO:0003214
GO:0003274
GO:0003417
GO:0003430
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005024
GO:0005026
GO:0005524
GO:0005539
GO:0005886
GO:0005901
GO:0006468
GO:0006915
GO:0007155
GO:0007178
GO:0007179
GO:0007219
GO:0007224
GO:0007369
GO:0007399
GO:0007420
GO:0007507
GO:0009410
GO:0009897
GO:0009986
GO:0010468
GO:0010634
GO:0010718
GO:0016020
GO:0016301
GO:0016361
GO:0016604
GO:0016740
GO:0019209
GO:0030154
GO:0030324
GO:0032924
GO:0033993
GO:0034713
GO:0035162
GO:0035909
GO:0038023
GO:0042127
GO:0043235
GO:0045121
GO:0045766
GO:0046332
GO:0046872
GO:0048179
GO:0048185
GO:0048513
GO:0048514
GO:0048701
GO:0048844
GO:0048856
GO:0050431
GO:0051094
GO:0051138
GO:0051216
GO:0051239
GO:0060021
GO:0060391
GO:0060395
GO:0060412
GO:0060425
GO:0060433
GO:0060434
GO:0060439
GO:0060440
GO:0060443
GO:0060463
GO:0061520
GO:0062009
GO:0070021
GO:0070723
GO:0071363
GO:0072091
GO:0098772
GO:0140096
GO:1905007
GO:1905317
GO:1990086
GO:1990428
GO:2000379
GO:2000563
GO:2000736
Participates
as an input of
TGFBR3 complex binds to TGFBR2 (Canis familiaris)
CBL binds TGFBR2 (Canis familiaris)
Dimeric TGF-beta-1 binds to the receptor (Canis familiaris)
as a component of
TGFB1,TGFB2:pTGFBR3:TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2:CBL [plasma membrane] (Canis familiaris)
TGFB1,TGFB2:TGFBR3:TGFBR2 [plasma membrane] (Canis familiaris)
TGFBR2 homodimer [plasma membrane] (Canis familiaris)
Other forms of this molecule
TGFBR2 [plasma membrane]
Inferred From
TGFBR2 [plasma membrane]
(Homo sapiens)
Cross References
RefSeq
XP_038426554.1
,
XP_038288013.1
,
XP_038313070.1
ENSEMBL
ENSCAFP00845031574
,
ENSCAFG00845022794
,
ENSCAFT00845040315
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