Reactome | MIB2 [cytosol]

MIB2 [cytosol]

Stable Identifier

R-CFA-1472879

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

MIB2, A0A8I3NS04

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:A0A8I3NS04

Gene Names

MIB2

Reference Genes

ENSEMBL:ENSCAFG00845015419.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845015419.1 MIB2

Other Identifiers

479566

CfaAffx.29376.1.S1_s_at

GO:0000151

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0005886

GO:0008270

GO:0016567

GO:0016740

GO:0031410

GO:0036211

GO:0043226

GO:0046872

GO:0061630

GO:0140096

Participates

as an input of

MIB2 binds RIPK1 within TNF-α:TNFR1:TRADD:RIPK1:TRAF2 (Canis familiaris)
MIB2 binds CFLAR (Canis familiaris)
MIB2 binds CYLD (Canis familiaris)

as a component of

TNF-α:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] (Canis familiaris)
CFLAR:MIB2:Ub:UBE2D1 [cytosol] (Canis familiaris)
MIB2:CYLD:UBE2D2 [cytosol] (Canis familiaris)
TNF-α:TNFR1:TRADD:polyUb-RIPK1:TRAF2:MIB2 [plasma membrane] (Canis familiaris)

as an output of

MIB2 ubiquitinates CFLAR (Canis familiaris)
MIB2 ubiquitinates CYLD at K338, K530 (Canis familiaris)

as a member of

E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)

Inferred From

MIB2 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000197530

Ensembl

ENSCAFP00845021644, ENSCAFG00845015419, ENSCAFT00845027510