Reactome | SOCS6 [cytosol]

SOCS6 [cytosol]

Stable Identifier

R-CFA-1469969

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

SOCS6, J9PB60

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Neddylation (Canis familiaris)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Canis familiaris)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SOCS6 [cytosol] (Canis familiaris)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SOCS6 [cytosol] (Canis familiaris)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SOCS6 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SOCS6 [cytosol] (Canis familiaris)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SOCS6 [cytosol] (Canis familiaris)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SOCS6 [cytosol] (Canis familiaris)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SOCS6 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        CUL5-box protein [cytosol] (Canis familiaris)
        
        SOCS6 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:J9PB60

Gene Names

SOCS6

Reference Genes

BioGPS Gene:100856303 SOCS6

ENSEMBL:ENSCAFG00000000036

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00000000036 SOCS6

KEGG Gene (Canis lupus familiaris):100856303 SOCS6

Monarch:100856303 SOCS6

NCBI Gene:100856303 SOCS6

Reference Transcript

Other Identifiers

100856303

Cfa.2103.1.A1_at

CfaAffx.1026.1.S1_at

GO:0001772

GO:0002376

GO:0003674

GO:0005575

GO:0005886

GO:0005942

GO:0006464

GO:0006629

GO:0007155

GO:0007165

GO:0008150

GO:0009056

GO:0009968

GO:0010498

GO:0016567

GO:0030234

GO:0032991

GO:0035556

GO:0040007

GO:0040008

GO:0043551

GO:0046854

GO:0046935

GO:0050868

Participates

as a member of

CUL5-box protein [cytosol] (Canis familiaris)

as an input of

Active FLT3 binds to SOCS6 (Canis familiaris)

as a component of

active FLT3:SOCS6 [plasma membrane] (Canis familiaris)

Inferred From

SOCS6 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_013977942.1, XP_013977908.1, XP_013977963.1, XP_013977929.1, XP_013977918.1, XP_013977885.1

OpenTargets

ENSG00000170677

Ensembl

ENSCAFT00000000054, ENSCAFG00000000036, ENSCAFP00000043038

VGNC

56921