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TIMP2 [extracellular region]
Stable Identifier
R-CFA-1454879
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
Q9TTY1
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Canis familiaris)
Degradation of the extracellular matrix (Canis familiaris)
Activation of Matrix Metalloproteinases (Canis familiaris)
Autocatalytic activation of bound proMMP2 (Canis familiaris)
MMP14:TIMP2:MMP2 intermediate form [plasma membrane] (Canis familiaris)
MMP14:TIMP2 [plasma membrane] (Canis familiaris)
TIMP2 [extracellular region] (Canis familiaris)
MMP14:TIMP:MMP2 [plasma membrane] (Canis familiaris)
MMP14:TIMP2 [plasma membrane] (Canis familiaris)
TIMP2 [extracellular region] (Canis familiaris)
Initial activation of proMMP2 by MMP14 (Canis familiaris)
MMP14:TIMP2:MMP2 intermediate form [plasma membrane] (Canis familiaris)
MMP14:TIMP2 [plasma membrane] (Canis familiaris)
TIMP2 [extracellular region] (Canis familiaris)
MMP14:TIMP2:proMMP2 [plasma membrane] (Canis familiaris)
MMP14:TIMP2 [plasma membrane] (Canis familiaris)
TIMP2 [extracellular region] (Canis familiaris)
MMP14 (MT1-MMP) binds TIMP2 (Canis familiaris)
MMP14:TIMP2 [plasma membrane] (Canis familiaris)
TIMP2 [extracellular region] (Canis familiaris)
TIMP2 [extracellular region] (Canis familiaris)
MMP14:TIMP2 binds proMMP2 (Canis familiaris)
MMP14:TIMP2 [plasma membrane] (Canis familiaris)
TIMP2 [extracellular region] (Canis familiaris)
MMP14:TIMP2:proMMP2 [plasma membrane] (Canis familiaris)
MMP14:TIMP2 [plasma membrane] (Canis familiaris)
TIMP2 [extracellular region] (Canis familiaris)
Immune System (Canis familiaris)
Innate Immune System (Canis familiaris)
Neutrophil degranulation (Canis familiaris)
Exocytosis of ficolin-rich granule lumen proteins (Canis familiaris)
Ficolin-rich granule lumen proteins [extracellular region] (Canis familiaris)
TIMP2 [extracellular region] (Canis familiaris)
Exocytosis of specific granule lumen proteins (Canis familiaris)
Specific granule lumen proteins [extracellular region] (Canis familiaris)
TIMP2 [extracellular region] (Canis familiaris)
Exocytosis of tertiary granule lumen proteins (Canis familiaris)
Tertiary granule lumen proteins [extracellular region] (Canis familiaris)
TIMP2 [extracellular region] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by TGFB family members (Canis familiaris)
Signaling by TGFBR3 (Canis familiaris)
TGFBR3 PTM regulation (Canis familiaris)
TGFBR3_mem cleavage by MMPs (Canis familiaris)
TIMP2 [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:Q9TTY1
Reference Genes
BioGPS Gene:403633
ENSEMBL:ENSCAFG00000058977
KEGG:cfa:403633
Monarch:403633
NCBI Gene:403633
UCSC:Q9TTY1
Reference Transcript
RefSeq:NM_001003082.1
Participates
as an input of
MMP14 (MT1-MMP) binds TIMP2 (Canis familiaris)
as a component of
MMP14:TIMP2 [plasma membrane] (Canis familiaris)
as a member of
Specific granule lumen proteins [extracellular region] (Canis familiaris)
Ficolin-rich granule lumen proteins [extracellular region] (Canis familiaris)
Tertiary granule lumen proteins [extracellular region] (Canis familiaris)
This entity regulates
Negatively
TGFBR3_mem cleavage by MMPs
(Canis familiaris)
Other forms of this molecule
TIMP2 [specific granule lumen]
TIMP2 [ficolin-1-rich granule lumen]
TIMP2 [tertiary granule lumen]
Inferred From
TIMP2 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_001003082.1
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