Reactome | phospho-FCER1G [plasma membrane]

phospho-FCER1G [plasma membrane]

Stable Identifier

R-CFA-141096

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

p-Y65,Y76-FCER1G, A0A8I3QSK6

Locations in the PathwayBrowser

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Hemostasis (Canis familiaris)

- Platelet activation, signaling and aggregation (Canis familiaris)
  - GPVI-mediated activation cascade (Canis familiaris)
    - Binding of Syk tyrosine kinase (Canis familiaris)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Canis familiaris)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Canis familiaris)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
    - Fyn/Lyn-mediated phosphorylation of FcR1 gamma (Canis familiaris)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Canis familiaris)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
    - GPVI stimulates PI3K beta, gamma (Canis familiaris)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Canis familiaris)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
    - SYK autophosphorylates (Canis familiaris)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Canis familiaris)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Canis familiaris)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
    - p-Y348-SYK dissociates (Canis familiaris)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Canis familiaris)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
      - GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:p-Y348-SYK [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I [plasma membrane] (Canis familiaris)
        
        GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN [plasma membrane] (Canis familiaris)
        
        GP VI : phosphorylated Fc Epsilon R1 gamma complex [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)

Immune System (Canis familiaris)

- Innate Immune System (Canis familiaris)
  - C-type lectin receptors (CLRs) (Canis familiaris)
    - Dectin-2 family (Canis familiaris)
      - LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
      - PLCG2 translocates from cytosol to plasma membrane (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
      - SYK autophosphorylates (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
      - SYK binds to p-Y65,Y76-FCER1G (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
      - SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Canis familiaris)
        
        pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer:TDM,alpha-mannan [plasma membrane] (Canis familiaris)
        
        CLEC4E:p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        p-Y65,Y76-FCER1G dimer [plasma membrane] (Canis familiaris)
        
        phospho-FCER1G [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3QSK6

Gene Names

FCER1G

Reference Genes

BioGPS Gene:403798 FCER1G

ENSEMBL:ENSCAFG00845029387.1

KEGG:cfa:403798 FCER1G

Monarch:403798 FCER1G

NCBI Gene:403798 FCER1G

UCSC:A0A8I3QSK6 FCER1G

Reference Transcript

RefSeq:NM_001003171.2 FCER1G

Other Identifiers

403798

CfaAffx.19951.1.S1_s_at

GO:0001798

GO:0001805

GO:0001812

GO:0002283

GO:0002292

GO:0002376

GO:0002431

GO:0002554

GO:0004888

GO:0005886

GO:0006911

GO:0007165

GO:0007166

GO:0007229

GO:0009897

GO:0009986

GO:0010543

GO:0016020

GO:0016064

GO:0016192

GO:0019767

GO:0019863

GO:0019864

GO:0019886

GO:0030154

GO:0030316

GO:0030593

GO:0031623

GO:0032733

GO:0032753

GO:0032755

GO:0032760

GO:0032765

GO:0032998

GO:0033001

GO:0033024

GO:0033026

GO:0038094

GO:0038095

GO:0038156

GO:0042590

GO:0042742

GO:0042802

GO:0042803

GO:0043303

GO:0043306

GO:0045087

GO:0045576

GO:0048870

GO:0050766

GO:0050776

GO:0050778

GO:0061024

GO:0071404

GO:0072659

GO:0098542

GO:0098797

GO:2000010

Participates

as a component of

Other forms of this molecule

FCER1G [ficolin-1-rich granule membrane]

FCER1G [tertiary granule membrane]

phospho-FCER1G [plasma membrane]

FCER1G [plasma membrane]

Inferred From

p-Y65,Y76-FCER1G [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 65 (in Homo sapiens)

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 76 (in Homo sapiens)

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001003171.2

ENSEMBL

ENSCAFP00845040815, ENSCAFT00845052025, ENSCAFG00845029387

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