Reactome | phospho-ERBB4 [plasma membrane]

phospho-ERBB4 [plasma membrane]

Stable Identifier

R-CFA-1250319

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform, A0A8I3S0T0

Locations in the PathwayBrowser

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Signal Transduction (Canis familiaris)

- Intracellular signaling by second messengers (Canis familiaris)
  - PIP3 activates AKT signaling (Canis familiaris)
    - Negative regulation of the PI3K/AKT network (Canis familiaris)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
        
        PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
        
        Activator:PI3K [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
    - PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
      - Activator:PI3K [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
        
        RAS GEFs [plasma membrane] (Canis familiaris)
        
        GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
- Signaling by Receptor Tyrosine Kinases (Canis familiaris)
  - Signaling by ERBB2 (Canis familiaris)
    - Downregulation of ERBB2 signaling (Canis familiaris)
      - MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers:MATK [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
      - PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)
        
        Heterodimers of p-ERBB2 dephosphorylated at Y1248 [plasma membrane] (Canis familiaris)
        
        Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        Phosphorylated p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
    - ERBB2 Regulates Cell Motility (Canis familiaris)
      - MEMO1 binds RHOA:GTP:DIAPH1 (Canis familiaris)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
      - Phosphorylated ERBB2 heterodimers bind MEMO1 (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
    - GRB2 events in ERBB2 signaling (Canis familiaris)
      - GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
      - RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4 heterodimers [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
    - PI3K events in ERBB2 signaling (Canis familiaris)
      - Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
      - PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Canis familiaris)
        
        Phosphorylated ERBB2:ERBB4cyt1 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
    - SHC1 events in ERBB2 signaling (Canis familiaris)
      - SHC1 phosphorylation by ERBB2 heterodimers (Canis familiaris)
        
        SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
    - Trans-autophosphorylation of ERBB2 heterodimers (Canis familiaris)
      - p-6Y-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-6Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
    - Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Canis familiaris)
      - Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGFLs:p-ERBB4cyt1:p-7Y-ERBB2 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
  - Signaling by ERBB4 (Canis familiaris)
    - PI3K events in ERBB4 signaling (Canis familiaris)
      - Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Canis familiaris)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
      - Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Canis familiaris)
        
        PI3K:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
    - SHC1 events in ERBB4 signaling (Canis familiaris)
      - Phosphorylation of SHC1 by ERBB4 homodimers (Canis familiaris)
        
        SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
      - RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Canis familiaris)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
      - Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Canis familiaris)
        
        GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
      - SHC1 binds P-ERBB4 isoform dimers (Canis familiaris)
        
        SHC1:p-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
        
        p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)
    - Trans-autophosphorylation of ERBB4 homodimers (Canis familiaris)
      - p-ERBB4 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4cyt1 homodimers [plasma membrane] (Canis familiaris)
        
        p-ERBB4jmAcyt1 [plasma membrane] (Canis familiaris)
        
        NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)
        
        phospho-ERBB4 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3S0T0

Gene Names

ERBB4

Reference Genes

BioGPS Gene:488508 ERBB4

ENSEMBL:ENSCAFG00845018700.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845018700.1 ERBB4

Monarch:488508 ERBB4

NCBI Gene:488508 ERBB4

Reference Transcript

RefSeq:XM_003640190.3 ERBB4

Other Identifiers

488508

Cfa.7779.1.A1_at

CfaAffx.21893.1.S1_s_at

CfaAffx.21903.1.S1_s_at

GO:0000166

GO:0000976

GO:0001755

GO:0003677

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005006

GO:0005154

GO:0005524

GO:0005634

GO:0005739

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0007005

GO:0007165

GO:0007166

GO:0007169

GO:0007173

GO:0007399

GO:0007416

GO:0007507

GO:0007595

GO:0008284

GO:0008285

GO:0009880

GO:0012501

GO:0016020

GO:0016301

GO:0016310

GO:0016323

GO:0016477

GO:0016740

GO:0021551

GO:0021889

GO:0023052

GO:0030154

GO:0030334

GO:0031594

GO:0034330

GO:0036211

GO:0038127

GO:0038130

GO:0038131

GO:0038135

GO:0038138

GO:0042127

GO:0042531

GO:0042734

GO:0042803

GO:0043226

GO:0043235

GO:0043653

GO:0045165

GO:0045893

GO:0046427

GO:0048856

GO:0048870

GO:0050811

GO:0051897

GO:0060045

GO:0060089

GO:0060644

GO:0060749

GO:0061026

GO:0070374

GO:0071364

GO:0072046

GO:0098590

GO:0098839

GO:0098978

GO:0098982

GO:0099645

GO:0140096

GO:2000010

Participates

as a component of

NRGs/EGF-like ligands:p-ERBB4cyt1 [plasma membrane] (Canis familiaris)

Other forms of this molecule

phospho-ERBB4 [mitochondrial matrix]

phospho-ERBB4 [nucleoplasm]

phospho-ERBB4 [cytosol]

phospho-ERBB4 [plasma membrane]

phospho-ERBB4 [cytosol]

phospho-ERBB4 [plasma membrane]

ERBB4 [plasma membrane]

phospho-ERBB4 [plasma membrane]

Inferred From

p-ERBB4cyt1 [plasma membrane] (Homo sapiens)

p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1056 (in Homo sapiens)

Coordinate

1056

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1188 (in Homo sapiens)

Coordinate

1188

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1242 (in Homo sapiens)

Coordinate

1242

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_003640238.1

OpenTargets

ENSG00000178568

Ensembl

ENSCAFT00845033485, ENSCAFP00845026212, ENSCAFG00845018700

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