Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
VCP [cytosol]
Stable Identifier
R-CFA-1181251
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
VCP, A0A8I3N153
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to chemical stress (Canis familiaris)
KEAP1-NFE2L2 pathway (Canis familiaris)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Asparagine N-linked glycosylation (Canis familiaris)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Canis familiaris)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Canis familiaris)
Deglycosylation complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
Deubiquitination (Canis familiaris)
Ovarian tumor domain proteases (Canis familiaris)
YOD1 binds VCP (Canis familiaris)
VCP [cytosol] (Canis familiaris)
YOD1:VCP [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
Neddylation (Canis familiaris)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Canis familiaris)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
Protein methylation (Canis familiaris)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Canis familiaris)
VCP [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog ligand biogenesis (Canis familiaris)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Canis familiaris)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
SYVN1 ubiquitinates Hh C-terminal fragments (Canis familiaris)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Canis familiaris)
Signaling by Rho GTPases (Canis familiaris)
RHO GTPase cycle (Canis familiaris)
RHOH GTPase cycle (Canis familiaris)
RHOH binds effectors at the plasma membrane (Canis familiaris)
RHOH effectors [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
RHOH:GTP:RHOH effectors [plasma membrane] (Canis familiaris)
RHOH effectors [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Canis familiaris)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
ERAD complex [endoplasmic reticulum membrane] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
VCP [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3N153
Gene Names
VCP
Reference Genes
BioGPS Gene:481590 VCP
ENSEMBL:ENSCAFG00845005647.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845005647.1 VCP
KEGG Gene (Canis lupus familiaris):481590 VCP
Monarch:481590 VCP
NCBI Gene:481590 VCP
Reference Transcript
RefSeq:XM_847533.4 VCP
Other Identifiers
481590
CfaAffx.3906.1.S1_s_at
GO:0000502
GO:0003824
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005783
GO:0005789
GO:0005811
GO:0005829
GO:0006091
GO:0006281
GO:0006302
GO:0006511
GO:0006734
GO:0006886
GO:0006914
GO:0006974
GO:0010494
GO:0010498
GO:0010918
GO:0016192
GO:0016236
GO:0016567
GO:0016787
GO:0016887
GO:0019079
GO:0019903
GO:0019904
GO:0019985
GO:0023052
GO:0030163
GO:0030433
GO:0030970
GO:0031334
GO:0031593
GO:0031625
GO:0032436
GO:0032510
GO:0032991
GO:0034098
GO:0034605
GO:0035617
GO:0035800
GO:0035861
GO:0036211
GO:0036435
GO:0036503
GO:0036513
GO:0042288
GO:0042802
GO:0043161
GO:0043226
GO:0043531
GO:0044389
GO:0045202
GO:0045732
GO:0045879
GO:0046034
GO:0048471
GO:0055086
GO:0061857
GO:0065003
GO:0070842
GO:0071712
GO:0072389
GO:0090263
GO:0097352
GO:0098772
GO:0106300
GO:0120186
GO:0140036
GO:0140657
GO:1901135
GO:1903006
GO:1903715
GO:1903843
GO:1903862
GO:1904288
GO:1904949
GO:1905634
GO:1990381
GO:1990730
GO:2001171
Participates
as a candidate of
RHOH effectors [cytosol] (Canis familiaris)
as an input of
YOD1 binds VCP (Canis familiaris)
VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP (Canis familiaris)
as a component of
YOD1:VCP [cytosol] (Canis familiaris)
HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] (Canis familiaris)
VCP hexamer [cytosol] (Canis familiaris)
Other forms of this molecule
VCP [cytosol]
VCP [nucleoplasm]
VCP [azurophil granule lumen]
VCP [secretory granule lumen]
VCP [extracellular region]
VCP [ficolin-1-rich granule lumen]
Inferred From
VCP [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_852626.1
OpenTargets
ENSG00000165280
Ensembl
ENSCAFG00845005647
,
ENSCAFP00845007818
,
ENSCAFT00845010017
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text