Reactome | ATP6V1B2 [cytosol]

ATP6V1B2 [cytosol]

Stable Identifier

R-CEL-912598

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

Q19626

Locations in the PathwayBrowser

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Cellular responses to stimuli (Caenorhabditis elegans)

- Cellular responses to stress (Caenorhabditis elegans)
  - Cellular response to starvation (Caenorhabditis elegans)
    - Amino acids regulate mTORC1 (Caenorhabditis elegans)
      - RRAGA,B exchanges GDP for GTP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
      - RRAGA,B hydrolyzes GTP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
      - RRAGC,D exchanges GTP for GDP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
      - RRAGC,D hydrolyzes GTP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
      - mTORC1 binds RHEB:GTP (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase:Ragulator [lysosomal membrane] (Caenorhabditis elegans)
        
        v-ATPase [lysosomal membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)

Immune System (Caenorhabditis elegans)

- Innate Immune System (Caenorhabditis elegans)
  - ROS and RNS production in phagocytes (Caenorhabditis elegans)
    - Intraphagosomal pH is lowered to 5 by V-ATPase (Caenorhabditis elegans)
      - V-ATPase [phagocytic vesicle membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by Insulin receptor (Caenorhabditis elegans)
    - Insulin receptor recycling (Caenorhabditis elegans)
      - ATP6AP1 binds V-ATPase (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
      - Endosome acidification (Caenorhabditis elegans)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)

Transport of small molecules (Caenorhabditis elegans)

- Ion channel transport (Caenorhabditis elegans)
  - ATP6AP1 binds V-ATPase (Caenorhabditis elegans)
    - V-ATPase [endosome membrane] (Caenorhabditis elegans)
      - ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
    - V-ATPase:ATP6AP1 [endosome membrane] (Caenorhabditis elegans)
      - V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
- Iron uptake and transport (Caenorhabditis elegans)
  - Transferrin endocytosis and recycling (Caenorhabditis elegans)
    - ATP6AP1 binds V-ATPase (Caenorhabditis elegans)
      - V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
      - V-ATPase:ATP6AP1 [endosome membrane] (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)
    - Acidification of Tf:TfR1 containing endosome (Caenorhabditis elegans)
      - V-ATPase:ATP6AP1 [endosome membrane] (Caenorhabditis elegans)
        
        V-ATPase [endosome membrane] (Caenorhabditis elegans)
        
        ATP6V1 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B trimer [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B [cytosol] (Caenorhabditis elegans)
        
        Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)
        
        ATP6V1B2 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q19626

Reference Genes

BioGPS Gene:180692

CTD Gene:180692

ENSEMBL:WBGene00006921

KEGG:cel:CELE_F20B6.2

Monarch:180692

NCBI Gene:180692

UCSC:Q19626

Wormbase:WBGene00006921

Reference Transcript

RefSeq:NM_076310.8

Other Identifiers

180692

GO:0000166

GO:0001666

GO:0001956

GO:0005524

GO:0006811

GO:0007035

GO:0015988

GO:0030003

GO:0033180

GO:0043068

GO:0046034

GO:0046961

GO:0051453

GO:0055085

GO:0055086

GO:0060142

GO:0065008

GO:0098609

GO:1901135

GO:1902600

GO:1904747

Participates

as a member of

Homologues of ATP6V1B2 [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

ATP6V1B1 [cytosol]

Inferred From

ATP6V1B2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_508711.1

ENSEMBL

WBGene00006921, F20B6.2.1, F20B6.2.1

PRO

Q19626

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