Reactome | cal-2 [nucleoplasm]

cal-2 [nucleoplasm]

Stable Identifier

R-CEL-9016871-2

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

CALM1, G5EEG0

Locations in the PathwayBrowser

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Immune System (Caenorhabditis elegans)

- Innate Immune System (Caenorhabditis elegans)
  - C-type lectin receptors (CLRs) (Caenorhabditis elegans)
    - CLEC7A (Dectin-1) signaling (Caenorhabditis elegans)
      - CLEC7A (Dectin-1) induces NFAT activation (Caenorhabditis elegans)
        
        Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)
        
        NFAT:CaN:CaM [nucleoplasm] (Caenorhabditis elegans)
        
        CaN:CaM:Ca2+ [nucleoplasm] (Caenorhabditis elegans)
        
        CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ [nucleoplasm] (Caenorhabditis elegans)
        
        CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CALM1 [nucleoplasm] (Caenorhabditis elegans)
        
        cal-2 [nucleoplasm] (Caenorhabditis elegans)
  - Fc epsilon receptor (FCERI) signaling (Caenorhabditis elegans)
    - FCERI mediated Ca+2 mobilization (Caenorhabditis elegans)
      - Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)
        
        NFAT:CaN:CaM [nucleoplasm] (Caenorhabditis elegans)
        
        CaN:CaM:Ca2+ [nucleoplasm] (Caenorhabditis elegans)
        
        CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ [nucleoplasm] (Caenorhabditis elegans)
        
        CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CALM1 [nucleoplasm] (Caenorhabditis elegans)
        
        cal-2 [nucleoplasm] (Caenorhabditis elegans)

Neuronal System (Caenorhabditis elegans)

- Transmission across Chemical Synapses (Caenorhabditis elegans)
  - Neurotransmitter receptors and postsynaptic signal transmission (Caenorhabditis elegans)
    - Activation of NMDA receptors and postsynaptic events (Caenorhabditis elegans)
      - Post NMDA receptor activation events (Caenorhabditis elegans)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Caenorhabditis elegans)
        
        CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
        
        CaMKK:CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CALM1 [nucleoplasm] (Caenorhabditis elegans)
        
        cal-2 [nucleoplasm] (Caenorhabditis elegans)
        
        p-CaMKK:CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CALM1 [nucleoplasm] (Caenorhabditis elegans)
        
        cal-2 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Intracellular signaling by second messengers (Caenorhabditis elegans)
  - DAG and IP3 signaling (Caenorhabditis elegans)
    - CaM pathway (Caenorhabditis elegans)
      - Calmodulin induced events (Caenorhabditis elegans)
        
        CaMK IV-mediated phosphorylation of CREB (Caenorhabditis elegans)
        
        CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
        
        CaMKK:CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CALM1 [nucleoplasm] (Caenorhabditis elegans)
        
        cal-2 [nucleoplasm] (Caenorhabditis elegans)
        
        p-CaMKK:CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CALM1 [nucleoplasm] (Caenorhabditis elegans)
        
        cal-2 [nucleoplasm] (Caenorhabditis elegans)
- Signaling by GPCR (Caenorhabditis elegans)
  - GPCR downstream signalling (Caenorhabditis elegans)
    - G alpha (i) signalling events (Caenorhabditis elegans)
      - Opioid Signalling (Caenorhabditis elegans)
        
        G-protein mediated events (Caenorhabditis elegans)
        
        PLC beta mediated events (Caenorhabditis elegans)
        
        Ca-dependent events (Caenorhabditis elegans)
        
        CaM pathway (Caenorhabditis elegans)
        
        Calmodulin induced events (Caenorhabditis elegans)
        
        CaMK IV-mediated phosphorylation of CREB (Caenorhabditis elegans)
        
        CaMKK autophosphorylates in the nucleus (Caenorhabditis elegans)
        
        CaMKK:CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CALM1 [nucleoplasm] (Caenorhabditis elegans)
        
        cal-2 [nucleoplasm] (Caenorhabditis elegans)
        
        p-CaMKK:CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CALM1 [nucleoplasm] (Caenorhabditis elegans)
        
        cal-2 [nucleoplasm] (Caenorhabditis elegans)
- Signaling by WNT (Caenorhabditis elegans)
  - Beta-catenin independent WNT signaling (Caenorhabditis elegans)
    - Ca2+ pathway (Caenorhabditis elegans)
      - Translocation of NFATC1:CaN:CaM to nucleus (Caenorhabditis elegans)
        
        NFATC1:CaN:CaM [nucleoplasm] (Caenorhabditis elegans)
        
        CaN:CaM:Ca2+ [nucleoplasm] (Caenorhabditis elegans)
        
        CaN catalytic alpha/beta:Zn++:Fe3+:CaM:Ca2+ [nucleoplasm] (Caenorhabditis elegans)
        
        CALM1:4xCa2+ [nucleoplasm] (Caenorhabditis elegans)
        
        Homologues of CALM1 [nucleoplasm] (Caenorhabditis elegans)
        
        cal-2 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:G5EEG0

Gene Names

cal-2

Reference Genes

BioGPS Gene:182789 cal-2

ENSEMBL:WBGene00000286

KEGG:cel:CELE_C18E9.1 cal-2

Monarch:182789 cal-2

NCBI Gene:182789 cal-2

UCSC:G5EEG0 cal-2

Wormbase:WBGene00000286

Wormbase:WBGene00000286 cal-2

Reference Transcript

RefSeq:NM_063505.6 cal-2

Other Identifiers

182789

GO:0005509

GO:0005737

GO:0005813

GO:0005815

GO:0046872

Participates

as a member of

Homologues of CALM1 [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

cal-2 [cytosol]

cal-2 [extracellular region]

cal-2 [plasma membrane]

cal-2 [cytosol]

Inferred From

CALM1 [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

C18E9.1.1, C18E9.1.1, WBGene00000286

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