Reactome | rme-6 [cytosol]

rme-6 [cytosol]

Stable Identifier

R-CEL-8871123

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

GAPVD1, Q9GYH7

Locations in the PathwayBrowser

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Vesicle-mediated transport (Caenorhabditis elegans)

- Membrane Trafficking (Caenorhabditis elegans)
  - Clathrin-mediated endocytosis (Caenorhabditis elegans)
    - RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
      - GGC-RAB5:GDP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        rme-6 [cytosol] (Caenorhabditis elegans)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        GGC-RAB5:GDP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
        
        rme-6 [cytosol] (Caenorhabditis elegans)
  - Rab regulation of trafficking (Caenorhabditis elegans)
    - RAB GEFs exchange GTP for GDP on RABs (Caenorhabditis elegans)
      - RAB5 GEFs exchange GTP for GDP on RAB5 (Caenorhabditis elegans)
        
        RAB5 GEFs [cytosol] (Caenorhabditis elegans)
        
        rme-6 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q9GYH7

Gene Names

rme-6

Reference Genes

BioGPS Gene:180463 rme-6

ENSEMBL:WBGene00004377

KEGG:cel:CELE_F49E7.1 rme-6

Monarch:180463 rme-6

NCBI Gene:180463 rme-6

UCSC:Q9GYH7 rme-6

Wormbase:WBGene00004377

Wormbase:WBGene00004377 rme-6

Reference Transcript

Other Identifiers

180463

GO:0005085

GO:0005096

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0006897

GO:0016020

GO:0016192

GO:0018996

GO:0030136

GO:0030139

GO:0031267

GO:0031410

GO:0032794

GO:0043087

GO:0045334

GO:0051049

GO:0051223

GO:0098772

GO:2000369

Participates

as a member of

RAB5 GEFs [cytosol] (Caenorhabditis elegans)

as a component of

Inferred From

GAPVD1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_508208.2, NP_001379623.1

ENSEMBL

WBGene00004377, F49E7.1a.1, F49E7.1a.1

PRO

Q9GYH7

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P91857	20	rab-5 [Golgi membrane] (R-CEL-434334) rab-5 [cytoplasmic vesicle membrane] (R-CEL-434198) rab-5 [early endosome membrane] (R-CEL-8854157) rab-5 [early endosome membrane] (R-CEL-8875323) rab-5 [early endosome membrane] (R-CEL-8875327) rab-5 [early endosome membrane] (R-CEL-8875331) rab-5 [cytosol] (R-CEL-8870432) rab-5 [cytosol] (R-CEL-8873778) rab-5 [cytosol] (R-CEL-8870434) rab-5 [cytosol] (R-CEL-8873764) rab-5 [cytosol] (R-CEL-8870436) rab-5 [cytosol] (R-CEL-8873710) rab-5 [cytosol] (R-CEL-8873703) rab-5 [cytosol] (R-CEL-8870412) rab-5 [cytosol] (R-CEL-8870413) rab-5 [early endosome membrane] (R-CEL-2130175) rab-5 [clathrin-coated endocytic vesicle membrane] (R-CEL-8871125) rab-5 [clathrin-coated endocytic vesicle membrane] (R-CEL-8871129) rab-5 [clathrin-coated endocytic vesicle membrane] (R-CEL-8871126) rab-5 [cytosol] (R-CEL-2201187)	0.508	2

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