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unc-57 [cytosol]
Stable Identifier
R-CEL-8867732
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
SH3GL1, B1V8A0
Locations in the PathwayBrowser
Expand all
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by EGFR (Caenorhabditis elegans)
EGFR downregulation (Caenorhabditis elegans)
Assembly of EGFR complex in clathrin-coated vesicles (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
CBL-mediated ubiquitination of CIN85 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Caenorhabditis elegans)
Ub-CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGFR binds EPS15, EPN1, EPS15L1 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGFR non-clathrin mediated endocytosis (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGFR phosphorylates EPS15 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PTPN3 dephosphorylates EPS15 (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Signaling by MET (Caenorhabditis elegans)
Negative regulation of MET activity (Caenorhabditis elegans)
CBL recruits CIN85:endophilin to ubiquitinated MET (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
EPS15 and HGS bind ubiquitinated MET (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Caenorhabditis elegans)
HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Vesicle-mediated transport (Caenorhabditis elegans)
Membrane Trafficking (Caenorhabditis elegans)
Clathrin-mediated endocytosis (Caenorhabditis elegans)
BAR domain proteins recruit dynamin (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Cargo recognition for clathrin-mediated endocytosis (Caenorhabditis elegans)
Epsin family proteins bind ubiquitinated cargo (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Clathrin recruits PIK3C2A (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Clathrin recruits auxilins to the clathrin-coated vesicle (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
Endophilins recruit synaptojanins to the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
F- and N- BAR domain proteins bind the clathrin-coated pit (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
RAB5 and GAPVD1 bind AP-2 (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Caenorhabditis elegans)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Caenorhabditis elegans)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
CLASP proteins:cargo [plasma membrane] (Caenorhabditis elegans)
EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
ubiquitinated cargo [plasma membrane] (Caenorhabditis elegans)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Caenorhabditis elegans)
CIN85:endophilin [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
SH3GLs [cytosol] (Caenorhabditis elegans)
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
unc-57 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:B1V8A0
Gene Names
unc-57
Reference Genes
BioGPS Gene:172078 unc-57
CTD Gene:172078 unc-57
ENSEMBL:WBGene00006791
KEGG:cel:CELE_T04D1.3 unc-57
Monarch:172078 unc-57
NCBI Gene:172078 unc-57
UCSC:B1V8A0 unc-57
Wormbase:WBGene00006791
Wormbase:WBGene00006791 unc-57
Reference Transcript
RefSeq:NM_001129041.3 unc-57
RefSeq:NM_001047216.3 unc-57
RefSeq:NM_001047215.5 unc-57
RefSeq:NM_001129040.5 unc-57
Other Identifiers
172078
GO:0005515
GO:0005737
GO:0006897
GO:0008021
GO:0012501
GO:0016020
GO:0016192
GO:0031410
GO:0031594
GO:0045202
GO:0070266
GO:0072583
GO:0098793
GO:0098978
Participates
as a component of
SH3GL1 dimer [cytosol] (Caenorhabditis elegans)
Other forms of this molecule
unc-57 [Golgi membrane]
unc-57 [plasma membrane]
unc-57 [cytosol]
unc-57 [cytosol]
Inferred From
SH3GL1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001122512.1
,
NP_001122513.1
,
NP_001040680.1
,
NP_001040681.1
ENSEMBL
T04D1.3d.1
,
T04D1.3d.1
,
WBGene00006791
PRO
B1V8A0
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