Reactome | ubc-18 [cytosol]

ubc-18 [cytosol]

Stable Identifier

R-CEL-8864201

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

Ub-C86-UBE2L3, Q21633

Locations in the PathwayBrowser

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Autophagy (Caenorhabditis elegans)

- Macroautophagy (Caenorhabditis elegans)
  - Selective autophagy (Caenorhabditis elegans)
    - Mitophagy (Caenorhabditis elegans)
      - PINK1-PRKN Mediated Mitophagy (Caenorhabditis elegans)
        
        PRKN ubiquitinates MOM substrates (Caenorhabditis elegans)
        
        Ub:Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Caenorhabditis elegans)
        
        Ub-UBE2D2,UBE2D3,UBE2N:UBE2V1,UBE2L3 [cytosol] (Caenorhabditis elegans)
        
        ubc-18 [cytosol] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Post-translational protein modification (Caenorhabditis elegans)
  - Protein ubiquitination (Caenorhabditis elegans)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Caenorhabditis elegans)
      - UBA1 conjugates ubiquitin to cytosolic E2 enzymes (Caenorhabditis elegans)
        
        Ub:E2 (UBA1 substrate) [cytosol] (Caenorhabditis elegans)
        
        Ub-conjugated E2 enzyme (UBA1 substrate) [cytosol] (Caenorhabditis elegans)
        
        ubc-18 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q21633

Gene Names

ubc-18

Reference Genes

BioGPS Gene:175985 ubc-18

ENSEMBL:WBGene00006713

KEGG:cel:CELE_R01H2.6 ubc-18

Monarch:175985 ubc-18

NCBI Gene:175985 ubc-18

UCSC:Q21633 ubc-18

Wormbase:WBGene00006713

Wormbase:WBGene00006713 ubc-18

Reference Transcript

RefSeq:NM_066140.7 ubc-18

Other Identifiers

175985

GO:0000209

GO:0003824

GO:0005515

GO:0005634

GO:0006511

GO:0008340

GO:0009887

GO:0016567

GO:0016740

GO:0031625

GO:0032446

GO:0048557

GO:0061631

GO:0140096

Participates

as a member of

as a component of

Ub:UBE2L3 [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

ubc-18 [nucleoplasm]

ubc-18 [cytosol]

Inferred From

Ub-C86-UBE2L3 [cytosol] (Homo sapiens)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 86 (in Homo sapiens)

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_498541.1

ENSEMBL

R01H2.6.1, WBGene00006713, R01H2.6.1

IntEnz

2.3.2.23

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9N2Z7	3	wwp-1 [cytosol] (R-CEL-975995) wwp-1 [cytosol] (R-CEL-976037) wwp-1 [cytosol] (R-CEL-6807279)	0.635	3
UniProt:O01964 O01964			0.488	2
UniProt:Q9NA31 Q9NA31			0.488	2
UniProt:Q20874	1	RNF14 [cytosol] (R-CEL-5688974)	0.488	2
UniProt:O01965	1	ARIH1 [cytosol] (R-CEL-1678825)	0.488	2

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