Reactome | rpl-4 [cytosol]

rpl-4 [cytosol]

Stable Identifier

R-CEL-72474

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

RPL4, O02056

Locations in the PathwayBrowser

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Metabolism of RNA (Caenorhabditis elegans)

- Nonsense-Mediated Decay (NMD) (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-4 [cytosol] (Caenorhabditis elegans)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-4 [cytosol] (Caenorhabditis elegans)
    - SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-4 [cytosol] (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-4 [cytosol] (Caenorhabditis elegans)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        60S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        rpl-4 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O02056

Gene Names

rpl-4

Reference Genes

BioGPS Gene:172074 rpl-4

ENSEMBL:WBGene00004415

KEGG:cel:CELE_B0041.4 rpl-4

Monarch:172074 rpl-4

NCBI Gene:172074 rpl-4

UCSC:O02056 rpl-4

Wormbase:WBGene00004415

Wormbase:WBGene00004415 rpl-4

Reference Transcript

RefSeq:NM_059015.8 rpl-4

Other Identifiers

172074

GO:0003723

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0008340

GO:0022625

GO:1990904

Participates

as a component of

Inferred From

RPL4 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_491416.1

ENSEMBL

WBGene00004415, B0041.4.1, B0041.4.1

PRO

O02056

PDB

9BH5, 9CAI

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