Reactome | FAU [cytosol]

FAU [cytosol]

Stable Identifier

R-CEL-72371

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

O44821

Locations in the PathwayBrowser

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Metabolism of RNA (Caenorhabditis elegans)

- Nonsense-Mediated Decay (NMD) (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Caenorhabditis elegans)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
    - SMG6 hydrolyzes mRNA with premature termination codon (Caenorhabditis elegans)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Caenorhabditis elegans)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Caenorhabditis elegans)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Caenorhabditis elegans)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)

Metabolism of proteins (Caenorhabditis elegans)

- Translation (Caenorhabditis elegans)
  - Eukaryotic Translation Initiation (Caenorhabditis elegans)
    - Cap-dependent Translation Initiation (Caenorhabditis elegans)
      - Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Caenorhabditis elegans)
        
        Translation initiation complex formation (Caenorhabditis elegans)
        
        Formation of translation initiation complexes containing mRNA that does not circularize (Caenorhabditis elegans)
        
        43S complex [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        48S complex [cytosol] (Caenorhabditis elegans)
        
        43S complex [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Caenorhabditis elegans)
        
        43S complex [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Caenorhabditis elegans)
        
        43S complex [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
      - Formation of a pool of free 40S subunits (Caenorhabditis elegans)
        
        Release of 40S and 60S subunits from the 80S ribosome (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        eIF3 and eIF1A bind to the 40S subunit (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        40S:eIF3:eIF1A [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
      - Formation of the ternary complex, and subsequently, the 43S complex (Caenorhabditis elegans)
        
        Formation of the 43S pre-initiation complex (Caenorhabditis elegans)
        
        40S:eIF3:eIF1A [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        43S complex [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
      - GTP hydrolysis and joining of the 60S ribosomal subunit (Caenorhabditis elegans)
        
        The 60S subunit joins the translation initiation complex (Caenorhabditis elegans)
        
        40S:Met-tRNAi:mRNA [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        eIF5B:GTP is hydrolyzed and released (Caenorhabditis elegans)
        
        80S:Met-tRNAi:mRNA [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
      - Ribosomal scanning and start codon recognition (Caenorhabditis elegans)
        
        Ribosomal scanning (Caenorhabditis elegans)
        
        48S complex [cytosol] (Caenorhabditis elegans)
        
        43S complex [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        Start codon recognition (Caenorhabditis elegans)
        
        48S complex [cytosol] (Caenorhabditis elegans)
        
        43S complex [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
    - L13a-mediated translational silencing of Ceruloplasmin expression (Caenorhabditis elegans)
      - Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Caenorhabditis elegans)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Caenorhabditis elegans)
        
        43S complex [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Caenorhabditis elegans)
        
        43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Caenorhabditis elegans)
        
        43S complex [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
  - Ribosome-associated quality control (Caenorhabditis elegans)
    - PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA (Caenorhabditis elegans)
      - ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released (Caenorhabditis elegans)
        
        ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Caenorhabditis elegans)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Caenorhabditis elegans)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
      - ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide (Caenorhabditis elegans)
        
        ABCE1:ADP:40S ribosomal subunit [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Caenorhabditis elegans)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
      - PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide (Caenorhabditis elegans)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Caenorhabditis elegans)
        
        80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
    - ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA (Caenorhabditis elegans)
      - ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit (Caenorhabditis elegans)
        
        K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Caenorhabditis elegans)
        
        K63polyUb-80S ribosome [cytosol] (Caenorhabditis elegans)
        
        K63polyUb-40S ribosomal subunit [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Caenorhabditis elegans)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
      - ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome (Caenorhabditis elegans)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
        
        ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide [cytosol] (Caenorhabditis elegans)
        
        80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
  - SRP-dependent cotranslational protein targeting to membrane (Caenorhabditis elegans)
    - Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Caenorhabditis elegans)
      - SRP:polypeptide+signal:ribosome [cytosol] (Caenorhabditis elegans)
        
        ribosome:mRNA:polypeptide+signal [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)
      - ribosome:mRNA:polypeptide+signal [cytosol] (Caenorhabditis elegans)
        
        80S ribosome [cytosol] (Caenorhabditis elegans)
        
        40S ribosomal complex [cytosol] (Caenorhabditis elegans)
        
        Homologues of FAU [cytosol] (Caenorhabditis elegans)
        
        FAU [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:O44821

Reference Genes

BioGPS Gene:173558

ENSEMBL:WBGene00018659

KEGG:cel:CELE_F52C6.2

Monarch:173558

NCBI Gene:173558

UCSC:O44821

Wormbase:WBGene00018659

Other Identifiers

173558

GO:0005515

GO:0005634

GO:0005737

GO:0016567

GO:0019941

GO:0031386

GO:0031625

Participates

as a member of

Homologues of FAU [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

FAU [nucleoplasm]

ISG15 [nucleoplasm]

K164-PCNA-G157-ISG15 [nucleoplasm]

ISG15 [cytosol]

Inferred From

FAU [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_494128.3

ENSEMBL

WBGene00018659, F52C6.2.1, F52C6.2.1

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