Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
pbs-4 [cytosol]
Stable Identifier
R-CEL-68744
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
PSMB2, P91477
Locations in the PathwayBrowser
Expand all
Cell Cycle (Caenorhabditis elegans)
Cell Cycle, Mitotic (Caenorhabditis elegans)
Mitotic G2-G2/M phases (Caenorhabditis elegans)
G2/M Transition (Caenorhabditis elegans)
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis (Caenorhabditis elegans)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Proteasome-mediated degradation of PolyUb-FBXL7 (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
S Phase (Caenorhabditis elegans)
Synthesis of DNA (Caenorhabditis elegans)
Switching of origins to a post-replicative state (Caenorhabditis elegans)
CDK-mediated phosphorylation and removal of Cdc6 (Caenorhabditis elegans)
Ubiquitinated Cdc6 is degraded by the proteasome (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Orc1 removal from chromatin (Caenorhabditis elegans)
Ubiquitinated Orc1 is degraded by the proteasome (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Ubiquitin-dependent degradation of Cyclin D (Caenorhabditis elegans)
Proteasome mediated degradation of Cyclin D1 (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to chemical stress (Caenorhabditis elegans)
KEAP1-NFE2L2 pathway (Caenorhabditis elegans)
26S proteasome degrades Ub-NFE2L2 (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Cellular response to hypoxia (Caenorhabditis elegans)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Caenorhabditis elegans)
Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
DNA Replication (Caenorhabditis elegans)
Synthesis of DNA (Caenorhabditis elegans)
Switching of origins to a post-replicative state (Caenorhabditis elegans)
CDK-mediated phosphorylation and removal of Cdc6 (Caenorhabditis elegans)
Ubiquitinated Cdc6 is degraded by the proteasome (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Orc1 removal from chromatin (Caenorhabditis elegans)
Ubiquitinated Orc1 is degraded by the proteasome (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
Antigen processing-Cross presentation (Caenorhabditis elegans)
Cross-presentation of soluble exogenous antigens (endosomes) (Caenorhabditis elegans)
Proteasomal clevage of exogenous antigen (26S proteasome catalyst) (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Antigen processing: Ub, ATP-independent proteasomal degradation (Caenorhabditis elegans)
Proteasomal cleavage of intracellular substrate (PA28-alpha-beta-20S proteasome catalyst) (Caenorhabditis elegans)
PA28-alpha-beta-20S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Antigen processing: Ubiquitination & Proteasome degradation (Caenorhabditis elegans)
Proteasomal cleavage of substrate (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Regulation of T cell activation by CD28 family (Caenorhabditis elegans)
Co-inhibition by PD-1 (Caenorhabditis elegans)
Regulation of PD-L1(CD274) expression (Caenorhabditis elegans)
Regulation of PD-L1(CD274) Post-translational modification (Caenorhabditis elegans)
SPOP-mediated proteasomal degradation of PD-L1(CD274) (Caenorhabditis elegans)
SPOP-mediated degradation of CD274 by 26S Proteosome (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Metabolism of polyamines (Caenorhabditis elegans)
Regulation of ornithine decarboxylase (ODC) (Caenorhabditis elegans)
26S proteosome degrades ODC holoenzyme complex (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Deubiquitination (Caenorhabditis elegans)
UCH proteinases (Caenorhabditis elegans)
ADRM1 binds 26S proteasome (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
ADRM1:26S proteasome [cytosol] (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
ADRM1:26S proteaseome binds UCHL5 (Caenorhabditis elegans)
ADRM1:26S proteasome [cytosol] (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
ADRM1:26S proteasome:UCHL5 [cytosol] (Caenorhabditis elegans)
ADRM1:26S proteasome [cytosol] (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Ub-specific processing proteases (Caenorhabditis elegans)
ADRM1:26S proteaseome binds USP14 (Caenorhabditis elegans)
ADRM1:26S proteasome [cytosol] (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
ADRM1:26S proteasome:USP14 [cytosol] (Caenorhabditis elegans)
ADRM1:26S proteasome [cytosol] (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Neddylation (Caenorhabditis elegans)
26S proteasome degrades HIFalpha (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
26S proteasome degrades Ub-NFE2L2 (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Proteasome assembly (Caenorhabditis elegans)
Formation of the 26S proteasome (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Formation of the PA28-alpha-beta-20S proteasome (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
PA28-alpha-beta-20S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Formation of the PA28gamma-20S proteasome (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
PA28gamma-20S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Formation of the preholoproteasome (Caenorhabditis elegans)
Half-proteasome [cytosol] (Caenorhabditis elegans)
Immature 20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Preholoproteasome [cytosol] (Caenorhabditis elegans)
Half-proteasome [cytosol] (Caenorhabditis elegans)
Immature 20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Translation (Caenorhabditis elegans)
Ribosome-associated quality control (Caenorhabditis elegans)
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide (Caenorhabditis elegans)
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
Intracellular signaling by second messengers (Caenorhabditis elegans)
PIP3 activates AKT signaling (Caenorhabditis elegans)
PTEN Regulation (Caenorhabditis elegans)
Regulation of PTEN stability and activity (Caenorhabditis elegans)
Proteasome degrades polyubiquitinated PTEN (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Signaling by WNT (Caenorhabditis elegans)
Beta-catenin independent WNT signaling (Caenorhabditis elegans)
PCP/CE pathway (Caenorhabditis elegans)
Asymmetric localization of PCP proteins (Caenorhabditis elegans)
PRICKLE1 is degraded by the proteasome (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Degradation of beta-catenin by the destruction complex (Caenorhabditis elegans)
Degradation of ubiquitinated beta catenin by the proteasome (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
TCF dependent signaling in response to WNT (Caenorhabditis elegans)
Degradation of AXIN (Caenorhabditis elegans)
Ub-RibC-AXIN is degraded by the proteasome (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Degradation of DVL (Caenorhabditis elegans)
Ubiquitinated DVL1 is degraded by the proteasome (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
Transport of small molecules (Caenorhabditis elegans)
ABC-family protein mediated transport (Caenorhabditis elegans)
misfolded CFTR is degraded by the 26S proteasome (Caenorhabditis elegans)
26S proteasome [cytosol] (Caenorhabditis elegans)
20S core particle [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
pbs-4 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:P91477
Gene Names
pbs-4
Reference Genes
BioGPS Gene:171975 pbs-4
ENSEMBL:WBGene00003950
KEGG:cel:CELE_T20F5.2 pbs-4
Monarch:171975 pbs-4
NCBI Gene:171975 pbs-4
UCSC:P91477 pbs-4
Wormbase:WBGene00003950
Wormbase:WBGene00003950 pbs-4
Reference Transcript
RefSeq:NM_058860.6 pbs-4
Participates
as a component of
Immature 20S CP inner ring [cytosol] (Caenorhabditis elegans)
20S CP inner ring [cytosol] (Caenorhabditis elegans)
Other forms of this molecule
pbs-4 [nucleoplasm]
Inferred From
PSMB2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_491261.1
PRO
P91477
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
