Reactome | rpa-1 [nucleoplasm]

rpa-1 [nucleoplasm]

Stable Identifier

R-CEL-68461

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

RPA1, Q19537

Locations in the PathwayBrowser

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DNA Repair (Caenorhabditis elegans)

- Base Excision Repair (Caenorhabditis elegans)
  - Resolution of Abasic Sites (AP sites) (Caenorhabditis elegans)
    - Resolution of AP sites via the multiple-nucleotide patch replacement pathway (Caenorhabditis elegans)
      - PCNA-Dependent Long Patch Base Excision Repair (Caenorhabditis elegans)
        
        LIG1 binds APEX1 and PCNA at SSB (Caenorhabditis elegans)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        LIG1 bound to APEX1 and PCNA ligates SSB (Caenorhabditis elegans)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:SSB:(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        APEX1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        LIG1:APEX1:PCNA:POLD,POLE:RPA:RFC:dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        POLD,POLE-mediated DNA strand displacement synthesis (Caenorhabditis elegans)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        APEX1:FEN1:PCNA:POLD,POLE:RPA:RFC:SSB(3'poly-dNMP-displaced 5'ddRP flap)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
- DNA Damage Bypass (Caenorhabditis elegans)
  - Recognition of DNA damage by PCNA-containing replication complex (Caenorhabditis elegans)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA (Caenorhabditis elegans)
      - MonoUb:K164-PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
    - RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA (Caenorhabditis elegans)
      - PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - RAD18:UBE2B,RBX1:CUL4:DDB1:DTL:PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC:Damaged DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Caenorhabditis elegans)
    - Termination of translesion DNA synthesis (Caenorhabditis elegans)
      - POLD,POLE binds deISGylated PCNA after TLS (Caenorhabditis elegans)
        
        PCNA:POLD,POLE:RPA:RFC:TLS-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
    - Translesion Synthesis by POLH (Caenorhabditis elegans)
      - Elongation by POLH (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - Insertion of correct bases opposite the lesion by POLH (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - POLH binds monoUb:K164-PCNA at damaged TT-CPD-DNA template (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:TT-CPD-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - SPRTN binds monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH (Caenorhabditis elegans)
        
        NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA (Caenorhabditis elegans)
        
        NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
    - Translesion synthesis by POLI (Caenorhabditis elegans)
      - POLI incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)
        
        POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
    - Translesion synthesis by POLK (Caenorhabditis elegans)
      - POLK incorporates dNMP opposite to damaged DNA base (Caenorhabditis elegans)
        
        POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
    - Translesion synthesis by REV1 (Caenorhabditis elegans)
      - REV1 binds AP-dsDNA (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - REV1 inserts dCMP opposite to AP sites in DNA (Caenorhabditis elegans)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        REV1:MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC:AP-DNA Template [nucleoplasm] (Caenorhabditis elegans)
        
        MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
- DNA Double-Strand Break Repair (Caenorhabditis elegans)
  - Homology Directed Repair (Caenorhabditis elegans)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Caenorhabditis elegans)
      - Processing of DNA double-strand break ends (Caenorhabditis elegans)
        
        ATR phosphorylates RPA2 (Caenorhabditis elegans)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Caenorhabditis elegans)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Caenorhabditis elegans)
        
        RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Caenorhabditis elegans)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Caenorhabditis elegans)
        
        p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] (Caenorhabditis elegans)
        
        p-RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
- Nucleotide Excision Repair (Caenorhabditis elegans)
  - Global Genome Nucleotide Excision Repair (GG-NER) (Caenorhabditis elegans)
    - Dual Incision in GG-NER (Caenorhabditis elegans)
      - 5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Caenorhabditis elegans)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - DNA polymerases delta, epsilon or kappa bind the GG-NER site (Caenorhabditis elegans)
        
        GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
    - Gap-filling DNA repair synthesis and ligation in GG-NER (Caenorhabditis elegans)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:Incised DNA without lesion [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC:SSB-dsDNA [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
    - Dual incision in TC-NER (Caenorhabditis elegans)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Caenorhabditis elegans)
        
        TC-NER incision complex [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Caenorhabditis elegans)
        
        TC-NER incision complex [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Caenorhabditis elegans)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Caenorhabditis elegans)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        RPA heterotrimer [nucleoplasm] (Caenorhabditis elegans)
        
        rpa-1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q19537

Gene Names

rpa-1

Reference Genes

BioGPS Gene:174238 rpa-1

CTD Gene:174238 rpa-1

ENSEMBL:WBGene00017546

Monarch:174238 rpa-1

NCBI Gene:174238 rpa-1

Wormbase:WBGene00017546

Reference Transcript

RefSeq:NM_063205.4 rpa-1

Other Identifiers

174238

18482499

190813_at

A_12_P106302

CE04405

CE_WBGene00017546_A

CE_WBGene00017546_B

CE_WBGene00017546_C

CGZ0016829

F18A1.5

F18A1.5_1530-1589_0.932_9_B

F18A1.5_1650-1709_0.908_22_C

F18A1.5_1781-1840_0.948_2_A

F18A1_5P00626

F18A1_5P00799

F18A1_5P01650

GO:0003676

GO:0003677

GO:0005634

GO:0006260

GO:0006281

GO:0006310

GO:0043226

WBGene00017546

cea2.p.36859

Participates

as a component of

Inferred From

RPA1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_495606.1

PRO

Q19537

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