Reactome | ZC3H8 [nucleoplasm]

ZC3H8 [nucleoplasm]

Stable Identifier

R-CEL-6807406

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

Q22805

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Caenorhabditis elegans)

- RNA Polymerase II Transcription (Caenorhabditis elegans)
  - RNA polymerase II transcribes snRNA genes (Caenorhabditis elegans)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Caenorhabditis elegans)
        
        LEC [nucleoplasm] (Caenorhabditis elegans)
        
        ZC3H8 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Caenorhabditis elegans)
        
        LEC [nucleoplasm] (Caenorhabditis elegans)
        
        ZC3H8 [nucleoplasm] (Caenorhabditis elegans)
    - Integrator complex processes the 3' end of snRNA (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Caenorhabditis elegans)
        
        LEC [nucleoplasm] (Caenorhabditis elegans)
        
        ZC3H8 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Caenorhabditis elegans)
        
        LEC [nucleoplasm] (Caenorhabditis elegans)
        
        ZC3H8 [nucleoplasm] (Caenorhabditis elegans)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Caenorhabditis elegans)
        
        LEC [nucleoplasm] (Caenorhabditis elegans)
        
        ZC3H8 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Caenorhabditis elegans)
        
        LEC [nucleoplasm] (Caenorhabditis elegans)
        
        ZC3H8 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q22805

Reference Genes

BioGPS Gene:177643

CTD Gene:177643

ENSEMBL:WBGene00020827

KEGG:cel:CELE_T26A8.4

Monarch:177643

NCBI Gene:177643

UCSC:Q22805

Wormbase:WBGene00020827

Reference Transcript

RefSeq:NM_069034.5

Other Identifiers

177643

GO:0003723

GO:0005515

GO:0005634

GO:0006355

GO:0008270

GO:0043226

GO:0045892

GO:0046872

Participates

as a component of

LEC [nucleoplasm] (Caenorhabditis elegans)

Other forms of this molecule

ZC3H4 [nucleoplasm]

Inferred From

ZC3H8 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_501435.1

ENSEMBL

T26A8.4.2, T26A8.4.1, T26A8.4.2, T26A8.4.1, WBGene00020827

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q94131	5	phospho-pie-1 [cytosol] (R-CEL-450496-11) pie-1 [cytosol] (R-CEL-450562-11) phospho-pie-1 [cytosol] (R-CEL-450384-11) pie-1 [cytosol] (R-CEL-450547-11) phospho-pie-1 [cytosol] (R-CEL-450618-11)	0.621	3
UniProt:Q9N4P3 Q9N4P3			0.488	2
UniProt:E02H4.2 Q19039			0.488	2
UniProt:Q21648 Q21648			0.488	2
UniProt:Q9U2N7 Q9U2N7			0.488	2
UniProt:Q9N2Z7	3	wwp-1 [cytosol] (R-CEL-975995) wwp-1 [cytosol] (R-CEL-976037) wwp-1 [cytosol] (R-CEL-6807279)	0.488	2