Reactome | gtf-2f1 [nucleoplasm]

gtf-2f1 [nucleoplasm]

Stable Identifier

R-CEL-65565

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

GTF2F1, Q17558

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Caenorhabditis elegans)

- Processing of Capped Intron-Containing Pre-mRNA (Caenorhabditis elegans)
  - Formation of pre-mRNPs (Caenorhabditis elegans)
    - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
      - capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
  - mRNA 3'-end processing (Caenorhabditis elegans)
    - mRNA Polyadenylation (Caenorhabditis elegans)
      - Core CPA complex binds capped pre-mRNA (Caenorhabditis elegans)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Caenorhabditis elegans)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Caenorhabditis elegans)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Caenorhabditis elegans)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
      - PP1 dephosphorylates RNA Pol II (Caenorhabditis elegans)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex (RNA Pol II dephosphorylated on Ser5) [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
      - RBBP6 activates CPSF complex (Caenorhabditis elegans)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex (RNA Pol II dephosphorylated on Ser5) [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex (RNA Pol II dephosphorylated on Ser5) [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (dephosphorylated on Ser5):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
  - mRNA Splicing (Caenorhabditis elegans)
    - mRNA Splicing - Major Pathway (Caenorhabditis elegans)
      - Formation of the Spliceosomal Bact complex (Caenorhabditis elegans)
        
        Spliceosomal B complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal Bact complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
      - Formation of the Spliceosomal C complex containing intron lariat (Caenorhabditis elegans)
        
        Spliceosomal B* complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated, polyadenylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal C complex [nucleoplasm] (Caenorhabditis elegans)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
      - Formation of the Spliceosomal C* complex (Caenorhabditis elegans)
        
        Spliceosomal C complex [nucleoplasm] (Caenorhabditis elegans)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal C* complex [nucleoplasm] (Caenorhabditis elegans)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
      - Formation of the Spliceosomal P complex and exon ligation (Caenorhabditis elegans)
        
        Spliceosomal C* complex [nucleoplasm] (Caenorhabditis elegans)
        
        mRNA intron lariat, 3'exon:RNA Polymerase II [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        Spliceosomal P complex [nucleoplasm] (Caenorhabditis elegans)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
    - mRNA Splicing - Minor Pathway (Caenorhabditis elegans)
      - ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Caenorhabditis elegans)
        
        ATAC C Complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
      - Formation of AT-AC B Complex (Caenorhabditis elegans)
        
        ATAC A Complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        ATAC B Complex [nucleoplasm] (Caenorhabditis elegans)
        
        ATAC A Complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
      - Formation of AT-AC C complex (Caenorhabditis elegans)
        
        ATAC B Complex [nucleoplasm] (Caenorhabditis elegans)
        
        ATAC A Complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        ATAC C Complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-mRNA:CBC Complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
- mRNA Capping (Caenorhabditis elegans)
  - Activation of GT (Caenorhabditis elegans)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
  - Capping complex formation (Caenorhabditis elegans)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
    - Capping complex (initial) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
  - Dissociation of transcript with 5'-GMP from GT (Caenorhabditis elegans)
    - Capping complex (GpppN..) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
  - Formation of the CE:GMP intermediate complex (Caenorhabditis elegans)
    - Capping complex (intermediate) [nucleoplasm] (Caenorhabditis elegans)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Caenorhabditis elegans)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
    - Capping complex (hydrolyzed) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
  - Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Caenorhabditis elegans)
    - Capping complex (hydrolyzed) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
    - Capping complex (initial) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
  - Methylation of GMP-cap by RNA Methyltransferase (Caenorhabditis elegans)
    - Capping complex (with freed 5'- GMP) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
  - RNA Polymerase II CTD (phosphorylated) binds to CE (Caenorhabditis elegans)
    - Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
  - Recognition and binding of the mRNA cap by the cap-binding complex (Caenorhabditis elegans)
    - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
    - capped pre-mRNA:CBC:RNA Pol II (phosphorylated) complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA Polymerase II (phosphorylated):TFIIF:capped pre-mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
  - SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Caenorhabditis elegans)
    - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
    - RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Caenorhabditis elegans)
      - RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
  - Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Caenorhabditis elegans)
    - Capping complex (intermediate) [nucleoplasm] (Caenorhabditis elegans)
      - Covalent CE:GMP intermediate complex [nucleoplasm] (Caenorhabditis elegans)
        
        CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
    - Capping complex (GpppN..) [nucleoplasm] (Caenorhabditis elegans)
      - CE:Pol II CTD:Spt5 complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA polymerase II (phosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)

Signal Transduction (Caenorhabditis elegans)

- Signaling by Nuclear Receptors (Caenorhabditis elegans)
  - ESR-mediated signaling (Caenorhabditis elegans)
    - Estrogen-dependent gene expression (Caenorhabditis elegans)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Caenorhabditis elegans)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hyperphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II holoenzyme complex (hypophosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
- Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
  - Signaling by FGFR (Caenorhabditis elegans)
    - Signaling by FGFR2 (Caenorhabditis elegans)
      - FGFR2 alternative splicing (Caenorhabditis elegans)
        
        PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Caenorhabditis elegans)
        
        FGFR2 IIIc-specific splicing complex [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)
        
        capped, methylated pre-FGFR2 mRNA:CBC complex [nucleoplasm] (Caenorhabditis elegans)
        
        RNA Polymerase II (unphosphorylated):TFIIF complex [nucleoplasm] (Caenorhabditis elegans)
        
        TFIIF [nucleoplasm] (Caenorhabditis elegans)
        
        gtf-2f1 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q17558

Gene Names

gtf-2f1

Reference Genes

BioGPS Gene:173764 gtf-2f1

ENSEMBL:WBGene00015296

KEGG:cel:CELE_C01F1.1 gtf-2f1

Monarch:173764 gtf-2f1

NCBI Gene:173764 gtf-2f1

UCSC:Q17558 gtf-2f1

Wormbase:WBGene00015296

Wormbase:WBGene00015296 gtf-2f1

Reference Transcript

RefSeq:NM_062355.6 gtf-2f1

Other Identifiers

173764

GO:0001096

GO:0003677

GO:0005634

GO:0005674

GO:0006355

GO:0006367

GO:0016251

GO:0032968

Participates

as a component of

TFIIF [nucleoplasm] (Caenorhabditis elegans)

Inferred From

GTF2F1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_494756.1

ENSEMBL

WBGene00015296, C01F1.1.1, C01F1.1.1

Cite Us!