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MAPK3 [cytosol]
Stable Identifier
R-CEL-59284
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
P39745
Locations in the PathwayBrowser
Expand all
Developmental Biology (Caenorhabditis elegans)
Nervous system development (Caenorhabditis elegans)
Axon guidance (Caenorhabditis elegans)
L1CAM interactions (Caenorhabditis elegans)
Signal transduction by L1 (Caenorhabditis elegans)
MAP2K1 phosphorylates MAPK3 (Caenorhabditis elegans)
p-2S-MAP2K1:MAPK3 [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Thrombin signalling through proteinase activated receptors (PARs) (Caenorhabditis elegans)
Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) (Caenorhabditis elegans)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
F2R:ARRB1 binds MAPKs, SRC-1 (Caenorhabditis elegans)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
F2R:ARRB2 binds MAPKs, SRC-1 (Caenorhabditis elegans)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
SRC-1 bound to ARRB2 is not activated (Caenorhabditis elegans)
F2R:ARRB2:MAPKs:SRC-1 [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) (Caenorhabditis elegans)
F2R:ARRB1:MAPKs:SRC-1 [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Interferon Signaling (Caenorhabditis elegans)
Antimicrobial mechanism of IFN-stimulated genes (Caenorhabditis elegans)
ISG15 antiviral mechanism (Caenorhabditis elegans)
ISGylation of host proteins (Caenorhabditis elegans)
ISG15 targets [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
ISGylated host proteins [cytosol] (Caenorhabditis elegans)
ISG15 targets [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18 (Caenorhabditis elegans)
ISG15 targets [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
ISGylated host proteins [cytosol] (Caenorhabditis elegans)
ISG15 targets [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
Signal Transduction (Caenorhabditis elegans)
MAPK family signaling cascades (Caenorhabditis elegans)
MAPK1/MAPK3 signaling (Caenorhabditis elegans)
RAF-independent MAPK1/3 activation (Caenorhabditis elegans)
Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)
MAPK monomers and dimers [cytosol] (Caenorhabditis elegans)
MAPK3 dimer [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
MAPK3 (ERK1) activation (Caenorhabditis elegans)
MAP2K1 binds MAPK3 (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
p-2S-MAP2K1:MAPK3 [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
MAP2K1 phosphorylates MAPK3 (Caenorhabditis elegans)
p-2S-MAP2K1:MAPK3 [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
RAF/MAP kinase cascade (Caenorhabditis elegans)
MAP2K and MAPK activation (Caenorhabditis elegans)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
IL17RD binds p-2S MAP2Ks and MAPKs (Caenorhabditis elegans)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Caenorhabditis elegans)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Caenorhabditis elegans)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
Negative regulation of MAPK pathway (Caenorhabditis elegans)
Cytosolic DUSPs dephosphorylate MAPKs (Caenorhabditis elegans)
MAPK monomers and dimers [cytosol] (Caenorhabditis elegans)
MAPK3 dimer [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by NTRKs (Caenorhabditis elegans)
Signaling by NTRK1 (TRKA) (Caenorhabditis elegans)
Signalling to ERKs (Caenorhabditis elegans)
Prolonged ERK activation events (Caenorhabditis elegans)
Frs2-mediated activation (Caenorhabditis elegans)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Caenorhabditis elegans)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
MAPK3 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:P39745
Reference Genes
BioGPS Gene:175545
CTD Gene:175545
ENSEMBL:WBGene00003401
KEGG:cel:CELE_F43C1.2
Monarch:175545
NCBI Gene:175545
UCSC:P39745
Wormbase:WBGene00003401
Wormbase:WBGene00003401
Reference Transcript
RefSeq:NM_001381825.1
RefSeq:NM_001027413.4
Other Identifiers
175545
GO:0000165
GO:0000166
GO:0001556
GO:0002164
GO:0003006
GO:0003824
GO:0004672
GO:0004674
GO:0004707
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0006355
GO:0006468
GO:0007166
GO:0007265
GO:0016301
GO:0016740
GO:0022412
GO:0022414
GO:0030154
GO:0032436
GO:0035556
GO:0040025
GO:0045944
GO:0046872
GO:0048468
GO:0048477
GO:0048513
GO:0048856
GO:0050830
GO:0051321
GO:0098542
GO:0106310
GO:0140096
Participates
as a member of
ISG15 targets [cytosol] (Caenorhabditis elegans)
MAPKs [cytosol] (Caenorhabditis elegans)
as a component of
MAPK3 dimer [cytosol] (Caenorhabditis elegans)
p-2S-MAP2K1:MAPK3 [cytosol] (Caenorhabditis elegans)
as an input of
MAP2K1 binds MAPK3 (Caenorhabditis elegans)
Other forms of this molecule
MAPK1 [ficolin-1-rich granule lumen]
MAPK1 [extracellular region]
MAPK1 [azurophil granule lumen]
phospho-p-Y204-MAPK3-3 [cytosol]
phospho-p-T202-MAPK3 [cytosol]
phospho-p-T185-MAPK1 [cytosol]
MAPK1 [nucleoplasm]
MAPK3 [nucleoplasm]
MAPK1 [cytosol]
phospho-p-T185,Y187-MAPK1 [cytosol]
phospho-p-T202,Y204-MAPK3 [cytosol]
phospho-p-T202,Y204-MAPK3 [nucleoplasm]
phospho-p-T185,Y187-MAPK1 [nucleoplasm]
Inferred From
MAPK3 [cytosol]
(Homo sapiens)
Cross References
ENSEMBL
WBGene00003401
,
F43C1.2b.1
,
F43C1.2b.1
PRO
P39745
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O02289
2
phospho-gla-3 [cytosol]
(R-CEL-450496-3)
gla-3 [cytosol]
(R-CEL-450562-3)
0.621
3
UniProt:Q17695 SPDL1
0.553
2
UniProt:Q19203 UNC98
0.553
2
UniProt:W10D9.3 O17285
0.553
2
UniProt:P91820 LST1
0.553
2
UniProt:Q9XUF2 Q9XUF2
0.553
2
UniProt:Q21229 Q21229
0.553
2
UniProt:P91829
2
nhr-69 [nucleoplasm]
(R-CEL-211483-23)
nhr-69 [nucleoplasm]
(R-CEL-446162-23)
0.553
2
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