Reactome | ERCC6 [nucleoplasm]

ERCC6 [nucleoplasm]

Stable Identifier

R-CEL-54429

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

nucleoplasm

Synonyms

Q86D18

Locations in the PathwayBrowser

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DNA Repair (Caenorhabditis elegans)

- Nucleotide Excision Repair (Caenorhabditis elegans)
  - Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Caenorhabditis elegans)
    - Dual incision in TC-NER (Caenorhabditis elegans)
      - 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Caenorhabditis elegans)
        
        TC-NER incision complex [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
      - Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Caenorhabditis elegans)
        
        TC-NER incision complex [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
      - DNA polymerases delta, epsilon or kappa bind the TC-NER site (Caenorhabditis elegans)
        
        TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
      - ERCC2-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
        
        TC-NER pre-incision complex [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
      - ERCC3-facilitated RNA Pol II backtracking in TC-NER (Caenorhabditis elegans)
        
        TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
    - Formation of TC-NER Pre-Incision Complex (Caenorhabditis elegans)
      - ERCC6 binds stalled RNA Pol II (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
      - ERCC8 (CSA) binds stalled RNA Pol II (Caenorhabditis elegans)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Caenorhabditis elegans)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
      - ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Caenorhabditis elegans)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Caenorhabditis elegans)
        
        Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
      - UVSSA:USP7 deubiquitinates ERCC6 (Caenorhabditis elegans)
        
        TC-NER pre-incision complex [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Caenorhabditis elegans)
        
        Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
    - Gap-filling DNA repair synthesis and ligation in TC-NER (Caenorhabditis elegans)
      - Ligation of newly synthesized repair patch to incised DNA in TC-NER (Caenorhabditis elegans)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
      - Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Caenorhabditis elegans)
        
        TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)
        
        TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Caenorhabditis elegans)
        
        ERCC6 [nucleoplasm] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q86D18

Reference Genes

ENSEMBL:WBGene00010011

UCSC:Q86D18

Wormbase:WBGene00010011

Other Identifiers

181672

GO:0000166

GO:0003824

GO:0005524

GO:0005634

GO:0006281

GO:0006283

GO:0006325

GO:0006338

GO:0016787

GO:0051301

GO:0140097

GO:0140657

GO:0140658

Participates

as a component of

as an input of

ERCC6 binds stalled RNA Pol II (Caenorhabditis elegans)

Other forms of this molecule

Ub-ERCC6 [nucleoplasm]

Inferred From

ERCC6 [nucleoplasm] (Homo sapiens)

Cross References

ENSEMBL

F53H4.6.1, WBGene00010011, F53H4.6.1

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