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phospho-sek-4 [nucleoplasm]
Stable Identifier
R-CEL-450229-6
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
nucleoplasm
Synonyms
p-S218,T222-MAP2K3, Q58AU8
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular Senescence (Caenorhabditis elegans)
Oxidative Stress Induced Senescence (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Cytokine Signaling in Immune system (Caenorhabditis elegans)
Signaling by Interleukins (Caenorhabditis elegans)
Interleukin-17 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Innate Immune System (Caenorhabditis elegans)
Toll-like Receptor Cascades (Caenorhabditis elegans)
Toll Like Receptor 10 (TLR10) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 2 (TLR2) Cascade (Caenorhabditis elegans)
Toll Like Receptor TLR1:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor TLR6:TLR2 Cascade (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 3 (TLR3) Cascade (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 4 (TLR4) Cascade (Caenorhabditis elegans)
MyD88-independent TLR4 cascade (Caenorhabditis elegans)
TRIF (TICAM1)-mediated TLR4 signaling (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 5 (TLR5) Cascade (Caenorhabditis elegans)
MyD88 cascade initiated on plasma membrane (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Toll Like Receptor 9 (TLR9) Cascade (Caenorhabditis elegans)
MyD88 dependent cascade initiated on endosome (Caenorhabditis elegans)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Caenorhabditis elegans)
MAP kinase activation (Caenorhabditis elegans)
activated TAK1 mediates p38 MAPK activation (Caenorhabditis elegans)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
Phosphorylated MKK3/MKK6 migrates to nucleus (Caenorhabditis elegans)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Caenorhabditis elegans)
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q58AU8
Gene Names
sek-4
Reference Genes
BioGPS Gene:180811 sek-4
ENSEMBL:WBGene00018035
KEGG:cel:CELE_F35C8.2 sek-4
Monarch:180811 sek-4
NCBI Gene:180811 sek-4
UCSC:Q58AU8 sek-4
Wormbase:WBGene00018035
Wormbase:WBGene00018035 sek-4
Reference Transcript
RefSeq:NM_076514.8 sek-4
Other Identifiers
180811
GO:0000165
GO:0000166
GO:0003824
GO:0004672
GO:0004708
GO:0005524
GO:0005737
GO:0006468
GO:0006950
GO:0016301
GO:0016740
GO:0140096
Participates
as a member of
Homologues of p-S218,T222-MAP2K3 [nucleoplasm] (Caenorhabditis elegans)
Other forms of this molecule
sek-4 [cytosol]
phospho-sek-4 [cytosol]
Inferred From
p-S218,T222-MAP2K3 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 218 (in Homo sapiens)
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_508915.3
ENSEMBL
WBGene00018035
,
F35C8.2.1
,
F35C8.2.1
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