Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
cul-2 [cytosol]
Stable Identifier
R-CEL-416982
Type
Protein [EntityWithAccessionedSequence]
Species
Caenorhabditis elegans
Compartment
cytosol
Synonyms
CUL2, Q17390
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to hypoxia (Caenorhabditis elegans)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Caenorhabditis elegans)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
Proteasome proteolyzes ub-HIF-alpha (Caenorhabditis elegans)
VBC complex (with or without LIMD1) [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Caenorhabditis elegans)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol (Caenorhabditis elegans)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Class I MHC mediated antigen processing & presentation (Caenorhabditis elegans)
Antigen processing: Ubiquitination & Proteasome degradation (Caenorhabditis elegans)
Interaction of E3 with substrate and E2-Ub complex (Caenorhabditis elegans)
Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
Polyubiquitination of substrate (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
Release of E3 from polyubiquitinated substrate (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
E3:K48-polyubiquitinated substrate [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
Transfer of Ub from E2 to substrate and release of E2 (Caenorhabditis elegans)
Ag-substrate:E3:E2:Ub [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
E3:Ub:substrate [cytosol] (Caenorhabditis elegans)
E3 ligases in proteasomal degradation [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
Metabolism of proteins (Caenorhabditis elegans)
Post-translational protein modification (Caenorhabditis elegans)
Neddylation (Caenorhabditis elegans)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Caenorhabditis elegans)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Caenorhabditis elegans)
CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
CRL2 E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
CRL E3 ubiquitin ligases [cytosol] (Caenorhabditis elegans)
CRL2 E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Caenorhabditis elegans)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Caenorhabditis elegans)
CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Caenorhabditis elegans)
CRL2 E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
cul-2 [cytosol] (Caenorhabditis elegans)
External Reference Information
External Reference
UniProt:Q17390
Gene Names
cul-2
Reference Genes
BioGPS Gene:176806 cul-2
CTD Gene:176806 cul-2
ENSEMBL:WBGene00000837
KEGG:cel:CELE_ZK520.4 cul-2
Monarch:176806 cul-2
NCBI Gene:176806 cul-2
UCSC:Q17390 cul-2
Wormbase:WBGene00000837
Wormbase:WBGene00000837 cul-2
Other Identifiers
176806
GO:0005515
GO:0005634
GO:0005737
GO:0006511
GO:0007018
GO:0008104
GO:0008595
GO:0016567
GO:0019005
GO:0019100
GO:0019102
GO:0022414
GO:0030163
GO:0030238
GO:0030261
GO:0030674
GO:0031145
GO:0031146
GO:0031461
GO:0031462
GO:0031625
GO:0042078
GO:0043161
GO:0051232
GO:0051301
GO:0051759
GO:0060090
GO:1902104
Participates
as a component of
CRL2 E3 ubiquitin ligase [cytosol] (Caenorhabditis elegans)
RBX1-CUL2-EloB,C-VHL [cytosol] (Caenorhabditis elegans)
Other forms of this molecule
cul-2 [cytosol]
cul-2 [nucleoplasm]
Inferred From
CUL2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001023008.1
,
NP_001023007.1
,
NP_001367020.1
ENSEMBL
ZK520.4c.1
,
WBGene00000837
,
ZK520.4c.1
PRO
Q17390
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BKS1
2
elc-1 [nucleoplasm]
(R-CEL-112422)
elc-1 [cytosol]
(R-CEL-180535)
0.589
2
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text