Reactome | phospho-p-Y397-PTK2 [cytosol]

phospho-p-Y397-PTK2 [cytosol]

Stable Identifier

R-CEL-354068

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

Q95YD4

Locations in the PathwayBrowser

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Developmental Biology (Caenorhabditis elegans)

- Nervous system development (Caenorhabditis elegans)
  - Axon guidance (Caenorhabditis elegans)
    - EPH-Ephrin signaling (Caenorhabditis elegans)
      - EPHB-mediated forward signaling (Caenorhabditis elegans)
        
        Recruitment of p190RhoGEF to p-FAK (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Caenorhabditis elegans)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
    - Netrin-1 signaling (Caenorhabditis elegans)
      - DCC mediated attractive signaling (Caenorhabditis elegans)
        
        Activation of Cdc42 (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        Activation of Rac1 (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        DCC interacting NCK-1 (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        Phosphorylation of DCC by Fyn (Caenorhabditis elegans)
        
        NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        Recruitment of Src and Fyn to DCC:FADK1 (Caenorhabditis elegans)
        
        NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        RhoGTPase GEF's recruited to DCC (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Caenorhabditis elegans)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Caenorhabditis elegans)
        
        phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:Q95YD4

Reference Genes

BioGPS Gene:172135

CTD Gene:172135

ENSEMBL:WBGene00002213

KEGG Gene (Caenorhabditis elegans):CELE_C30F8.4

Monarch:172135

NCBI Gene:172135

UCSC:Q95YD4

Wormbase:WBGene00002213

Reference Transcript

Other Identifiers

172135

176874_at

18452196

A_12_P111725

C30F8.4

C30F8.4a

C30F8.4a_1715-1774_0.907_20_B

C30F8.4a_1803-1862_0.895_27_C

C30F8.4a_1997-2056_0.917_14_A

C30F8.4b

C30F8_4aP01673

C30F8_4aP02162

C30F8_4aP02438

CE30493

CE_WBGene00002213_A

CE_WBGene00002213_B

CGZ0006779

CGZ0006780

GO:0003824

GO:0004672

GO:0004713

GO:0005524

GO:0005856

GO:0005925

GO:0006468

GO:0007172

GO:0016740

GO:0023052

GO:0036211

GO:0043226

GO:0065003

GO:0140096

WBGene00002213

cea2.3.04565

cea2.d.01009

cea2.d.01015

Participates

as a component of

as an output of

Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Caenorhabditis elegans)

Other forms of this molecule

phospho-pY-PTK2 [cytosol]

phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]

phospho-p-Y194,Y397-PTK2 [cytosol]

PTK2B [cytosol]

phospho-PTK2B [cytosol]

PTK2(773-1052) [cytosol]

PTK2(1-772) [cytosol]

PTK2 [cytosol]

phospho-p-6Y-PTK2 [cytosol]

Inferred From

p-Y397-PTK2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 397 (in Homo sapiens)

Coordinate

397

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_740842.1, NP_740841.1

PRO

Q95YD4

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