Reactome | deb-1 [cytosol]

deb-1 [cytosol]

Stable Identifier

R-CEL-350753

Type

Protein [EntityWithAccessionedSequence]

Species

Caenorhabditis elegans

Compartment

cytosol

Synonyms

VCL, P19826

Locations in the PathwayBrowser

Expand all

Signal Transduction (Caenorhabditis elegans)

- MAPK family signaling cascades (Caenorhabditis elegans)
  - MAPK1/MAPK3 signaling (Caenorhabditis elegans)
    - RAF/MAP kinase cascade (Caenorhabditis elegans)
      - MAP2K and MAPK activation (Caenorhabditis elegans)
        
        Dissociation of RAS:RAF complex (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        Dual mechanism MAP2K inhibitors bind MAP2Ks (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        Dual mechanism MAPK inhibitors bind MAPKs (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        MAP2Ks and MAPKs bind to the activated RAF complex (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        RAF phosphorylates MAP2K dimer (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        Single mechanism MAPK inhibitors bind phosphorylated MAPK (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Caenorhabditis elegans)
        
        RAF/MAPK scaffolds [cytosol] (Caenorhabditis elegans)
        
        Focal Adhesion/Focal contacts [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to alphaIIbbeta3 [plasma membrane] (Caenorhabditis elegans)
        
        Vinculin bound to PIP2 [plasma membrane] (Caenorhabditis elegans)
        
        deb-1 [cytosol] (Caenorhabditis elegans)

External Reference Information

External Reference

UniProt:P19826

Gene Names

deb-1

Reference Genes

BioGPS Gene:177482 deb-1

CTD Gene:177482 deb-1

ENSEMBL:WBGene00000942

KEGG Gene (Caenorhabditis elegans):CELE_ZC477.9 deb-1

Monarch:177482 deb-1

NCBI Gene:177482 deb-1

UCSC:P19826 deb-1

Wormbase:WBGene00000942

Reference Transcript

Other Identifiers

174754_at

176518_at

177482

18560712

A_12_P110232

A_12_P118304

A_12_P131775

A_12_P131776

CE31396

CE31397

CE_WBGene00000942_A

CGZ0055962

GO:0003779

GO:0005198

GO:0005856

GO:0007155

GO:0008092

GO:0015629

GO:0043226

GO:0051015

WBGene00000942

ZC477.9

ZC477.9a

ZC477.9a_2562-2621_0.929_6_C

ZC477.9a_2805-2864_0.934_4_B

ZC477.9a_2943-3002_0.957_1_A

ZC477.9b

ZC477.9c

ZC477_9aP01934

ZC477_9aP02577

ZC477_9aP02815

ZC477_9bP00001

ZC477_9bP00018

ZC477_9bP00072

ZC477_9cP01856

ZC477_9cP01936

cea2.3.30888

cea2.d.07474

cea2.d.47800

cea2.d.47839

cea2.d.47883

Participates

as a component of

as a member of

Platelet releasate cytosolic proteins [cytosol] (Caenorhabditis elegans)

Other forms of this molecule

deb-1 [cytosol]

deb-1 [specific granule lumen]

deb-1 [secretory granule lumen]

deb-1 [extracellular region]

deb-1 [ficolin-1-rich granule lumen]

Inferred From

VCL [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_501105.2, NP_001293743.1, NP_001293747.1, NP_741437.1, NP_001293745.1, NP_501104.2, NP_001293744.1, NP_001293746.1

PRO

P19826

Cite Us!